16966615

Source:http://linkedlifedata.com/resource/pubmed/id/16966615

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0037083, umls-concept:C0151650, umls-concept:C0225332, umls-concept:C0670509, umls-concept:C0851285, umls-concept:C1332684, umls-concept:C1413191, umls-concept:C1710082
pubmed:issue	38
pubmed:dateCreated	2006-9-20
pubmed:abstractText	Fibrocytes are a distinct population of bloodborne cells that share markers of leukocytes as well as mesenchymal cells. We hypothesized that CCR7-positive fibrocytes migrate into the kidney in response to secondary lymphoid tissue chemokine (SLC/CCL21) and contribute to renal fibrosis. To investigate this hypothesis, renal fibrosis was induced by unilateral ureteral obstruction in mice. A considerable number of fibrocytes dual-positive for CD45 and type I collagen (ColI) or CD34 and ColI infiltrated the interstitium, reaching a peak on day 7. Most fibrocytes were positive for CCR7, and CCL21/CCR7 blockade reduced the number of infiltrating fibrocytes. CCL21 and MECA79 dual-positive vessels were also detected in the interstitium. The blockade of CCL21/CCR7 signaling by anti-CCL21 antibodies reduced renal fibrosis, which was confirmed by a decrease in fibrosis in CCR7-null mice with concomitant reduction in renal transcripts of pro alpha1 chain of ColI and TGF-beta1. The number of F4/80-positive macrophages decreased along with renal transcripts of monocyte chemoattractant protein 1 (MCP-1/CCL2) after the blockade of CCL21/CCR7 signaling. These findings suggest that CCR7-positive fibrocytes infiltrate the kidney via CCL21-positive vessels, thereby contributing to the pathogenesis of renal fibrosis. Thus, the CCL21/CCR7 signaling of fibrocytes may provide therapeutic targets for combating renal fibrosis.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-10233873, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-10469367, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-10515417, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-10520991, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-11160258, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-11342595, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-11373340, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-11390511, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-11591761, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-11918720, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-11919403, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-11967021, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-12163453, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-12218079, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-12707342, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-12808448, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-12817021, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-14566107, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-15034096, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-15215179, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-15237268, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-15286810, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-15743780, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-15778365, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-2313659, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-2466043, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-4173786, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-6842965, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-7935686, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-8256856, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-8731185, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-8790603, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-8903512, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-9238513, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-9419363, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-9551999, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-9585422, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-9734628, http://linkedlifedata.com/resource/pubmed/commentcorrection/16966615-9811526
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7505876
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, http://linkedlifedata.com/resource/pubmed/chemical/CCL21 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/CCR7 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Ccl2 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Ccl21c protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Ccr7 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2, http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL21, http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR7, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0027-8424
pubmed:author	pubmed-author:KanekoShuichiS, pubmed-author:LippMartinM, pubmed-author:MatsushimaKoujiK, pubmed-author:SakaiNorihikoN, pubmed-author:UehaSatoshiS, pubmed-author:WadaTakashiT, pubmed-author:YokoyamaHitoshiH
pubmed:issnType	Print
pubmed:day	19
pubmed:volume	103
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	14098-103
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:16966615-Animals, pubmed-meshheading:16966615-Antibodies, pubmed-meshheading:16966615-Chemokine CCL2, pubmed-meshheading:16966615-Chemokine CCL21, pubmed-meshheading:16966615-Chemokines, CC, pubmed-meshheading:16966615-Fibrosis, pubmed-meshheading:16966615-Humans, pubmed-meshheading:16966615-Kidney, pubmed-meshheading:16966615-Male, pubmed-meshheading:16966615-Mice, pubmed-meshheading:16966615-Mice, Inbred BALB C, pubmed-meshheading:16966615-Receptors, CCR7, pubmed-meshheading:16966615-Receptors, Chemokine, pubmed-meshheading:16966615-Signal Transduction, pubmed-meshheading:16966615-Ureter
pubmed:year	2006
pubmed:articleTitle	Secondary lymphoid tissue chemokine (SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis.
pubmed:affiliation	Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, and Division of Blood Purification, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan.

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