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rdf:type |
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lifeskim:mentions |
umls-concept:C0003451,
umls-concept:C0019409,
umls-concept:C0021311,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0205322,
umls-concept:C0271510,
umls-concept:C0549178,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C1880177,
umls-concept:C2698600
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pubmed:issue |
10
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pubmed:dateCreated |
2006-10-3
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pubmed:abstractText |
Numerous microbes establish persistent infections, accompanied by antigen-specific CD8 T cell activation. Pathogen-specific T cells in chronically infected hosts are often phenotypically and functionally variable, as well as distinct from T cells responding to nonpersistent infections; this phenotypic heterogeneity has been attributed to an ongoing reencounter with antigen. Paradoxically, maintenance of memory CD8 T cells to acutely resolved infections is antigen independent, whereas there is a dependence on antigen for T cell survival in chronically infected hosts. Using two chronic viral infections, we demonstrate that new naive antigen-specific CD8 T cells are primed after the acute phase of infection. These newly recruited T cells are phenotypically distinct from those primed earlier. Long-lived antiviral CD8 T cells are defective in self-renewal, and lack of thymic output results in the decline of virus-specific CD8 T cells, indicating that newly generated T cells preserve antiviral CD8 T cell populations during chronic infection. These findings reveal a novel role for antigen in maintaining virus-specific CD8 T cells during persistent infection and provide insight toward understanding T cell differentiation in chronic infection.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-10558996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-10558997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-10737796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-11242051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-11413318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-11927633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-12466842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-12594261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-12663797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-12810686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-12975459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-14764895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-15067066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-15130505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-15239090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-15448686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-15479725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-15505208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-15583014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-15657294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-15738052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-15756645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-15944301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-15956569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-16014905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-16147980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-1940352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-9858507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16966427-9933172
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
203
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2263-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16966427-Animals,
pubmed-meshheading:16966427-Antigens, Viral,
pubmed-meshheading:16966427-CD8-Positive T-Lymphocytes,
pubmed-meshheading:16966427-Cell Differentiation,
pubmed-meshheading:16966427-Female,
pubmed-meshheading:16966427-Flow Cytometry,
pubmed-meshheading:16966427-Lymphocytic choriomeningitis virus,
pubmed-meshheading:16966427-Mice,
pubmed-meshheading:16966427-Mice, Inbred C57BL,
pubmed-meshheading:16966427-Polyomavirus,
pubmed-meshheading:16966427-Virus Diseases
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pubmed:year |
2006
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pubmed:articleTitle |
Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection.
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pubmed:affiliation |
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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