rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
8
|
pubmed:dateCreated |
2006-9-12
|
pubmed:abstractText |
Survivin, a member of IAPs (inhibition of apoptosis proteins) family, has been revealed by many studies to inhibit the activation of caspase-3, caspase-7 and caspase-9, and thus increase the anti-apoptotic effect of cancer cells, which subsequently makes the cells to become resistant to chemotherapy in cancer treatment. Survivin is expressed in human oral squamous carcinoma cell line KB and its multiple-drug resistant (MDR) cell line KBv200. This study was to compare the apoptosis induced by silencing survivin gene between these two squamous cell lines.
|
pubmed:language |
chi
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
1000-467X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
25
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
933-40
|
pubmed:dateRevised |
2011-11-17
|
pubmed:meshHeading |
pubmed-meshheading:16965671-Antineoplastic Agents,
pubmed-meshheading:16965671-Apoptosis,
pubmed-meshheading:16965671-Caspase 3,
pubmed-meshheading:16965671-Cell Proliferation,
pubmed-meshheading:16965671-Drug Resistance, Multiple,
pubmed-meshheading:16965671-Drug Resistance, Neoplasm,
pubmed-meshheading:16965671-Flow Cytometry,
pubmed-meshheading:16965671-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16965671-Humans,
pubmed-meshheading:16965671-Inhibitor of Apoptosis Proteins,
pubmed-meshheading:16965671-KB Cells,
pubmed-meshheading:16965671-Microtubule-Associated Proteins,
pubmed-meshheading:16965671-Plasmids,
pubmed-meshheading:16965671-RNA, Messenger,
pubmed-meshheading:16965671-RNA Interference,
pubmed-meshheading:16965671-Transfection
|
pubmed:year |
2006
|
pubmed:articleTitle |
[Study on apoptosis of oral squamous carcinoma cell line KB and KBv200 induced by survivin RNAi].
|
pubmed:affiliation |
State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract,
Research Support, Non-U.S. Gov't
|