|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2006-10-20
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Over the last decade, the introduction of microarray technology has had a profound impact on gene expression research. The publication of studies with dissimilar or altogether contradictory results, obtained using different microarray platforms to analyze identical RNA samples, has raised concerns about the reliability of this technology. The MicroArray Quality Control (MAQC) project was initiated to address these concerns, as well as other performance and data analysis issues. Expression data on four titration pools from two distinct reference RNA samples were generated at multiple test sites using a variety of microarray-based and alternative technology platforms. Here we describe the experimental design and probe mapping efforts behind the MAQC project. We show intraplatform consistency across test sites as well as a high level of interplatform concordance in terms of genes identified as differentially expressed. This study provides a resource that represents an important first step toward establishing a framework for the use of microarrays in clinical and regulatory settings.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1087-0156
|
|
pubmed:author |
pubmed-author:LiL YLY,
pubmed-author:PanM JMJ,
pubmed-author:QuM MMM,
pubmed-author:DaiS JSJ,
pubmed-author:RégaPP,
pubmed-author:PyneG JGJ,
pubmed-author:LiuYingY,
pubmed-author:JensenRoderick VRV,
pubmed-author:BoysenCecilieC,
pubmed-author:HongHuixiaoH,
pubmed-author:TongWeidaW,
pubmed-author:FangHongH,
pubmed-author:ShiLemingL,
pubmed-author:ChenJames JJJ,
pubmed-author:WangYonghongY,
pubmed-author:ZhongShengS,
pubmed-author:PuriRaj KRK,
pubmed-author:ChudinEugeneE,
pubmed-author:QianFengF,
pubmed-author:TaoHanH,
pubmed-author:WalkerStephen JSJ,
pubmed-author:CebulaThomas ATA,
pubmed-author:ZhangLiangL,
pubmed-author:WolfingerRussR,
pubmed-author:WilsonMikeM,
pubmed-author:ZhangLuL,
pubmed-author:DorrisDavidD,
pubmed-author:ShippyRichardR,
pubmed-author:PusztaiLajosL,
pubmed-author:SzallasiZoltanZ,
pubmed-author:PerkinsRoger GRG,
pubmed-author:WarringtonJanet AJA,
pubmed-author:LiuChunmeiC,
pubmed-author:ThompsonKarol LKL,
pubmed-author:TezakZivanaZ,
pubmed-author:MyklebostOlaO,
pubmed-author:CortonJ ChristopherJC,
pubmed-author:JohnsonCharles DCD,
pubmed-author:HarrisStephen CSC,
pubmed-author:GuoXuX,
pubmed-author:ChengJingJ,
pubmed-author:LobenhoferEdward KEK,
pubmed-author:XiaoChunlinC,
pubmed-author:DaviesChristopherC,
pubmed-author:WilleyJames CJC,
pubmed-author:CollinsPatrick JPJ,
pubmed-author:SlikkerWilliamWJr,
pubmed-author:Thierry-MiegJeanJ,
pubmed-author:Thierry-MiegDanielleD,
pubmed-author:BertholetVincentV,
pubmed-author:DixDavid JDJ,
pubmed-author:KuoWinston PWP,
pubmed-author:LeClercJ EugeneJE,
pubmed-author:WangCharlesC,
pubmed-author:SchrothGary PGP,
pubmed-author:AmurShashiS,
pubmed-author:MaYunqingY,
pubmed-author:BaoWenjunW,
pubmed-author:WangSue JaneSJ,
pubmed-author:WongAlexA,
pubmed-author:HagerJanetJ,
pubmed-author:SchenaMarkM,
pubmed-author:HurbanPatrickP,
pubmed-author:KawasakiErnest SES,
pubmed-author:LuoYulingY,
pubmed-author:HauserCraig ACA,
pubmed-author:HanJingJ,
pubmed-author:FuscoeJames CJC,
pubmed-author:LiQuan-ZhenQZ,
pubmed-author:MagnusonScott RSR,
pubmed-author:FruehFelix WFW,
pubmed-author:RosenzweigBarry ABA,
pubmed-author:SetterquistRobert ARA,
pubmed-author:KnightCharles RCR,
pubmed-author:de LonguevilleFrancoiseF,
pubmed-author:LevyShawnS,
pubmed-author:StaedtlerFrankF,
pubmed-author:ChuTzu-MingTM,
pubmed-author:SunHongmeiH
|
