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rdf:type |
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lifeskim:mentions |
umls-concept:C0006104,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0035668,
umls-concept:C0037874,
umls-concept:C0243046,
umls-concept:C0597694,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1720154,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
1990-9-13
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pubmed:abstractText |
The effects of spermine and a synthetic analogue (PhTX-343) of the polyamine amide toxin, delta-philanthotoxin, on the responses of Xenopus oocytes to application of amino acids were examined using voltage clamp. The oocytes were injected with either total rat brain RNA or chick cerebrum, poly(A+)RNA. The responses to N-methyl-D-aspartate and L-kainate were potentiated by low concentrations (10(-11)-10(-7) M) of PhTX-343 and by 10(-5)-10(-4) M spermine. There was variability between oocytes in terms of their responsiveness to these compounds and recovery from their effects was slow and often incomplete. Prolonged or repeated applications of PhTX-343 and spermine eventually resulted in inhibition. Higher concentrations of these compounds always inhibited the responses to acidic amino acids. Low concentrations of PhTX-343 and spermine also potentiated the responses to nicotine and gamma-aminobutyric acid. These results are discussed in terms of the postulated polyamine binding site on the N-methyl-D-aspartate receptor.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Aspartic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Bee Venoms,
http://linkedlifedata.com/resource/pubmed/chemical/Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Oxadiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Poly A,
http://linkedlifedata.com/resource/pubmed/chemical/Polyamines,
http://linkedlifedata.com/resource/pubmed/chemical/Quisqualic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Spermine,
http://linkedlifedata.com/resource/pubmed/chemical/Wasp Venoms,
http://linkedlifedata.com/resource/pubmed/chemical/delta-philanthotoxin
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
51-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1696366-Amino Acids,
pubmed-meshheading:1696366-Animals,
pubmed-meshheading:1696366-Aspartic Acid,
pubmed-meshheading:1696366-Bee Venoms,
pubmed-meshheading:1696366-Brain,
pubmed-meshheading:1696366-Chickens,
pubmed-meshheading:1696366-Kainic Acid,
pubmed-meshheading:1696366-Male,
pubmed-meshheading:1696366-Membrane Potentials,
pubmed-meshheading:1696366-Microinjections,
pubmed-meshheading:1696366-N-Methylaspartate,
pubmed-meshheading:1696366-Neurotoxins,
pubmed-meshheading:1696366-Oocytes,
pubmed-meshheading:1696366-Oxadiazoles,
pubmed-meshheading:1696366-Poly A,
pubmed-meshheading:1696366-Polyamines,
pubmed-meshheading:1696366-Quisqualic Acid,
pubmed-meshheading:1696366-RNA,
pubmed-meshheading:1696366-RNA, Messenger,
pubmed-meshheading:1696366-Rats,
pubmed-meshheading:1696366-Rats, Inbred Strains,
pubmed-meshheading:1696366-Spermine,
pubmed-meshheading:1696366-Wasp Venoms,
pubmed-meshheading:1696366-Xenopus
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pubmed:year |
1990
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pubmed:articleTitle |
Spermine and philanthotoxin potentiate excitatory amino acid responses of Xenopus oocytes injected with rat and chick brain RNA.
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pubmed:affiliation |
Department of Zoology, University of Nottingham, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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