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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-10-23
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pubmed:abstractText |
Common variable immunodeficiency disease (CVID) is a primary immune disorder affecting B cells and characterized by hypogammaglobulinemia and recurrent infections. To elucidate the clinical and immunological heterogeneity of this condition, we have studied B and T cell subsets in 25 CVID patients. In eleven of them, we observed a remarkable relative expansion of a B cell subpopulation (CD19(hi)/CD21(lo) cells) characterized by the absence of CD23 and the reduced expression of the chemokine receptors CXCR5 and CCR7. Our analyses demonstrated in these patients that the expansion of CD19(hi)/CD21(lo) cells correlates with a selective decrease of circulating naïve and CD21(hi) memory B lymphocytes. The same group of patients displayed a simultaneous severe reduction of naïve CD4+ T cells associated with decreased levels of T cell receptor excision circles. These observations suggest that a combined defect in generation of B and T subpopulations may account for the abnormal immunophenotype characterizing this subgroup of CVID patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD19,
http://linkedlifedata.com/resource/pubmed/chemical/CCR7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CXCR5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR7,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR5,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Complement 3d
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1521-6616
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pubmed:author |
pubmed-author:BadolatoRaffaeleR,
pubmed-author:FontanaStefaniaS,
pubmed-author:GulinoAnna VirginiaAV,
pubmed-author:ImbertiLuisaL,
pubmed-author:MeiniAntonellaA,
pubmed-author:MorattoDanieleD,
pubmed-author:MoriLuigiL,
pubmed-author:NotarangeloLuigi DanieleLD,
pubmed-author:PirovanoSilviaS,
pubmed-author:PlebaniAlessandroA,
pubmed-author:SoresinaAnnarosaA
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pubmed:issnType |
Print
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
203-14
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pubmed:dateRevised |
2008-5-6
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pubmed:meshHeading |
pubmed-meshheading:16962827-Adolescent,
pubmed-meshheading:16962827-Adult,
pubmed-meshheading:16962827-Agammaglobulinemia,
pubmed-meshheading:16962827-Antigens, CD19,
pubmed-meshheading:16962827-B-Lymphocyte Subsets,
pubmed-meshheading:16962827-Case-Control Studies,
pubmed-meshheading:16962827-Child,
pubmed-meshheading:16962827-Child, Preschool,
pubmed-meshheading:16962827-Common Variable Immunodeficiency,
pubmed-meshheading:16962827-Female,
pubmed-meshheading:16962827-Humans,
pubmed-meshheading:16962827-Infant,
pubmed-meshheading:16962827-Male,
pubmed-meshheading:16962827-Middle Aged,
pubmed-meshheading:16962827-Receptors, CCR7,
pubmed-meshheading:16962827-Receptors, CXCR5,
pubmed-meshheading:16962827-Receptors, Chemokine,
pubmed-meshheading:16962827-Receptors, Complement 3d,
pubmed-meshheading:16962827-T-Lymphocyte Subsets
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pubmed:year |
2006
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pubmed:articleTitle |
Combined decrease of defined B and T cell subsets in a group of common variable immunodeficiency patients.
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pubmed:affiliation |
Istituto di Medicina Molecolare "Angelo Nocivelli", Clinica Pediatrica, Universita' di Brescia, Spedali Civili, Piazzale Spedali Civili 1, 25123 Brescia, Italy. daniele.moratto@gmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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