| pubmed-article:1696270 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1696270 | lifeskim:mentions | umls-concept:C0598800 | lld:lifeskim |
| pubmed-article:1696270 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:1696270 | lifeskim:mentions | umls-concept:C1135918 | lld:lifeskim |
| pubmed-article:1696270 | lifeskim:mentions | umls-concept:C0282547 | lld:lifeskim |
| pubmed-article:1696270 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:1696270 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:1696270 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:1696270 | lifeskim:mentions | umls-concept:C0205275 | lld:lifeskim |
| pubmed-article:1696270 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1696270 | pubmed:dateCreated | 1990-9-7 | lld:pubmed |
| pubmed-article:1696270 | pubmed:abstractText | The conversion of latent transforming growth factor beta (LTGF-beta) to the active species, transforming growth factor beta (TGF-beta), has been characterized in heterotypic cultures of bovine aortic endothelial (BAE) cells and bovine smooth muscle cells (SMCs). The formation of TGF-beta in co-cultures of BAE cells and SMCs was documented by a specific radioreceptor competition assay, while medium from homotypic cultures of BAE cells or SMCs contained no active TGF-beta as determined by this assay. The concentration of TGF-beta in the conditioned medium of heterotypic co-cultures was estimated to be 400-1,200 pg/ml using the inhibition of BAE cell migration as an assay. Northern blotting of poly A+ RNA extracted from both homotypic and heterotypic cultures of BAE cells and SMCs revealed that BAE cells produced both TGF-beta 1 and TGF-beta 2, while SMCs produced primarily TGF-beta 1. No change in the expression of these two forms of TGF-beta was apparent after 24 h in heterotypic cultures. Time course studies on the appearance of TGF-beta indicated that most of the active TGF-beta was generated within the first 12 h after the establishment of co-cultures. The generation of TGF-beta in co-cultures stimulated the production of the protease inhibitor plasminogen activator inhibitor-1 (PAI-1). The inclusion of neutralizing antibodies to TGF-beta in the co-culture medium blocked the observed increase in PAI-1 levels. The increased expression of PAI-1 subsequent to TGF-beta formation blocked the activation of the protease required for conversion of LTGF-beta to TGF-beta as the inclusion of neutralizing antibodies to PAI-1 in the co-culture medium resulted in prolonged production of TGF-beta. This effect was lost upon removal of the PAI-1 antibodies. Thus, the activation of LTGF-beta appears to be a self-regulating system. | lld:pubmed |
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| pubmed-article:1696270 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1696270 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1696270 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1696270 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1696270 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1696270 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:1696270 | pubmed:author | pubmed-author:SatoYY | lld:pubmed |
| pubmed-article:1696270 | pubmed:author | pubmed-author:RifkinD BDB | lld:pubmed |
| pubmed-article:1696270 | pubmed:author | pubmed-author:LyonsRR | lld:pubmed |
| pubmed-article:1696270 | pubmed:author | pubmed-author:TsuboiRR | lld:pubmed |
| pubmed-article:1696270 | pubmed:author | pubmed-author:MosesHH | lld:pubmed |
| pubmed-article:1696270 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1696270 | pubmed:volume | 111 | lld:pubmed |
| pubmed-article:1696270 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1696270 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1696270 | pubmed:pagination | 757-63 | lld:pubmed |
| pubmed-article:1696270 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1696270 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1696270 | pubmed:articleTitle | Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system. | lld:pubmed |
| pubmed-article:1696270 | pubmed:affiliation | Department of Cell Biology, New York University Medical Center, New York. | lld:pubmed |
| pubmed-article:1696270 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1696270 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1696270 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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