Source:http://linkedlifedata.com/resource/pubmed/id/16962325
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
22
|
| pubmed:dateCreated |
2006-10-9
|
| pubmed:abstractText |
Novel inhibitors of Trypanosoma brucei and mammalian UDP-Glc 4'-epimerase were identified by screening a small library of natural products and commercially available drug-like molecules. The inhibitors possess low micromolar potency against the T. brucei and human enzymes in vitro, display a degree of selectivity between the two enzymes, and are cytotoxic to cultured T. brucei and mammalian cells.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
5744-7
|
| pubmed:dateRevised |
2007-8-13
|
| pubmed:meshHeading |
pubmed-meshheading:16962325-Animals,
pubmed-meshheading:16962325-Enzyme Inhibitors,
pubmed-meshheading:16962325-Humans,
pubmed-meshheading:16962325-Models, Chemical,
pubmed-meshheading:16962325-Trypanocidal Agents,
pubmed-meshheading:16962325-Trypanosoma brucei brucei,
pubmed-meshheading:16962325-Trypanosomiasis, African,
pubmed-meshheading:16962325-UDPglucose 4-Epimerase
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness.
|
| pubmed:affiliation |
Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Validation Studies
|