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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-9-8
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pubmed:abstractText |
The leucine-rich repeat kinase 2 (LRRK2) G2019S mutation is the most common genetic determinant of Parkinson disease (PD) identified to date. It accounts for 1%-7% of PD in patients of European origin and 20%-40% in Ashkenazi Jews and North African Arabs with PD. Previous studies concluded that patients from these populations all shared a common Middle Eastern founder who lived in the 13th century. We tested this hypothesis by genotyping 25 microsatellite and single-nucleotide-polymorphism markers in 22 families with G2019S and observed two distinct haplotypes. Haplotype 1 was present in 19 families of Ashkenazi Jewish and European ancestry, whereas haplotype 2 occurred in three European American families. Using a maximum-likelihood method, we estimated that the families with haplotype 1 shared a common ancestor 2,250 (95% confidence interval 1,650-3,120) years ago, whereas those with haplotype 2 appeared to share a more recent founder. Our data suggest two separate founding events for G2019S in these populations, beginning at a time that coincides with the Jewish Diasporas.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-10090892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-10677323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-10677327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-10756141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-12446870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-12672864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-14624392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-15087508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-15172778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-15173230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-15374870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-15541308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-15541309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-15680455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-15680456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-15680457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-15700229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-15726496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-15795887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-16145815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-16187141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-16250030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-16272257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-16436781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-16436782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-16728648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-2841426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-7605419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-8599769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-9197268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16960813-9560156
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0002-9297
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pubmed:author |
pubmed-author:BirdThomas DTD,
pubmed-author:EdwardsKaren LKL,
pubmed-author:FactorStewart ASA,
pubmed-author:GriffithAlidaA,
pubmed-author:HigginsDonald SDS,
pubmed-author:HutterCarolyn MCM,
pubmed-author:KayDenise MDM,
pubmed-author:LeisBerta CBC,
pubmed-author:LopezAlexis NAN,
pubmed-author:NuttJohn GJG,
pubmed-author:PayamiHaydehH,
pubmed-author:RobertsJohn WJW,
pubmed-author:SamiiAliA,
pubmed-author:YearoutDoraD,
pubmed-author:ZabetianCyrus PCP
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pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
752-8
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pubmed:dateRevised |
2011-5-5
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pubmed:meshHeading |
pubmed-meshheading:16960813-Africa, Northern,
pubmed-meshheading:16960813-Amino Acid Substitution,
pubmed-meshheading:16960813-Case-Control Studies,
pubmed-meshheading:16960813-European Continental Ancestry Group,
pubmed-meshheading:16960813-Family,
pubmed-meshheading:16960813-Female,
pubmed-meshheading:16960813-Haplotypes,
pubmed-meshheading:16960813-Humans,
pubmed-meshheading:16960813-Jews,
pubmed-meshheading:16960813-Male,
pubmed-meshheading:16960813-Middle East,
pubmed-meshheading:16960813-Parkinson Disease,
pubmed-meshheading:16960813-Polymorphism, Single Nucleotide,
pubmed-meshheading:16960813-Protein-Serine-Threonine Kinases,
pubmed-meshheading:16960813-Software
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pubmed:year |
2006
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pubmed:articleTitle |
LRRK2 G2019S in families with Parkinson disease who originated from Europe and the Middle East: evidence of two distinct founding events beginning two millennia ago.
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pubmed:affiliation |
Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA. zabetian@u.washington.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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