Linked Life Data

16959517

Source:http://linkedlifedata.com/resource/pubmed/id/16959517

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6-7
pubmed:dateCreated
2006-11-3
pubmed:abstractText
Imaging in cancer plays a capital role to guide the clinician in his choice of therapies. We will discuss the new techniques available to predict and evaluate treatment response in oncology. The method of reference to evaluate treatment response is based on the measure of lesion size. Functional imaging doesn't evaluate size, but rather a physiological or molecular feature, which is probably modified earlier in response to treatment. Dynamic contrast-enhanced functional imaging of microcirculation follows the biodistribution of a contrast agent and analyses tumour vascularization. Diffusion-weighted Magnetic Resonance Imaging differentiates free and restrained water molecules in tissues, reflecting tumor cellularity. Nuclear Magnetic Resonance spectroscopy is an application of MRI that yields information on the metabolic content of a tissue. It detects relative quantities of various molecules which differ in tumour compared to normal tissue. Positon-emission tomography using (18)FDG is a nuclear medicine technique which gives information on tissue metabolism. Captation of FDG is proportional to the proliferative activity and the number of viable cells in a tumour. Human studies concerning these techniques are still quite preliminary, and the medical community must determine their potential in clinical practice to evaluate treatment response in oncology.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1278-3218
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
484-7
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
[Treatment response evaluation by functional imaging].
pubmed:affiliation
Service de Radiologie, Hôpital Européen Georges-Pompidou, 20, Rue Leblanc, 75015 Paris, France. laure.fournier@gmail.com
pubmed:publicationType
Journal Article, English Abstract