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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-12-5
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pubmed:abstractText |
Huntington's disease has an increase in the activated calpain, which is enhanced by the NMDA receptor activation. We investigated the neuroprotective effect of memantine in 3-nitropropionic acid (3NP)-induced striatal degeneration model. Either memantine (20 mg/kg/day) or PBS was intraperitoneally administered for five days with 3NP continuous infusion. In the memantine-treated group, the striatal lesion volume, the number of TUNEL+ cells, and Fluoro-Jade C+ degenerating neurons were all decreased. Memantine increased Bcl-xl and decreased Bax level. Memantine also exerted an inhibitory effect on the micro-calpain level and decreased the huntingtin proteolytic fragments. Those rats treated with memantine showed less degree of weight loss at 5 days. Subsequently, memantine was found to have neuroprotective effects and save striatal cells with decreasing calpain levels in the 3NP model of Huntington's disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-nitropropionic acid,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Calpain,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Huntington protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Memantine,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Nitro Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Propionic Acids
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
1118
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
199-207
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pubmed:meshHeading |
pubmed-meshheading:16959224-Animals,
pubmed-meshheading:16959224-Apoptosis Regulatory Proteins,
pubmed-meshheading:16959224-Calpain,
pubmed-meshheading:16959224-Cell Death,
pubmed-meshheading:16959224-Corpus Striatum,
pubmed-meshheading:16959224-Disease Models, Animal,
pubmed-meshheading:16959224-Down-Regulation,
pubmed-meshheading:16959224-Excitatory Amino Acid Antagonists,
pubmed-meshheading:16959224-Huntington Disease,
pubmed-meshheading:16959224-Male,
pubmed-meshheading:16959224-Memantine,
pubmed-meshheading:16959224-Nerve Degeneration,
pubmed-meshheading:16959224-Nerve Tissue Proteins,
pubmed-meshheading:16959224-Neurons,
pubmed-meshheading:16959224-Neuroprotective Agents,
pubmed-meshheading:16959224-Neurotoxins,
pubmed-meshheading:16959224-Nitro Compounds,
pubmed-meshheading:16959224-Nuclear Proteins,
pubmed-meshheading:16959224-Peptide Fragments,
pubmed-meshheading:16959224-Propionic Acids,
pubmed-meshheading:16959224-Rats,
pubmed-meshheading:16959224-Rats, Sprague-Dawley
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pubmed:year |
2006
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pubmed:articleTitle |
Memantine reduces striatal cell death with decreasing calpain level in 3-nitropropionic model of Huntington's disease.
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pubmed:affiliation |
Department of Neurology, Clinical Research Institute, Seoul National University Hospital, Chongro-Gu, Seoul, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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