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pubmed-article:1695866pubmed:abstractTextThe patch-clamp technique was utilized to characterize a cation channel in peptidergic nerve terminals isolated from a crustacean neurosecretory system. The cation channel exhibits the unique property of being activated by [Na+]. Distributions of open times demonstrate the presence of two open states with a shift of the distribution from predominantly short open times at [Na+] less than or equal to 10 mM to a predominantly long open state at [Na+] greater than or equal to 40 mM. Desensitization of channel activation occurs on prolonged exposure to [Na+] greater than 40 mM. Open probability increased steeply with [Na+] but was largely independent of membrane potential. Comparison of current-voltage relationships from single dissociated terminals and from those in the intact system show no differences in conductance or selectivity with nearly equal permeability to Na+ and K+, and impermeability to Cs+, divalent cations and anions. Flickering block occurred with [Ca2+]i greater than 1 microM. We propose that Na-activated cation (NAC) channels are activated by Na+ entering during action potentials and provide a sustained depolarizing current that can help sustain repetitive or bursting activity and subsequent facilitation of secretion from these nerve terminals.lld:pubmed
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pubmed-article:1695866pubmed:authorpubmed-author:CookeI MIMlld:pubmed
pubmed-article:1695866pubmed:authorpubmed-author:RubenPPlld:pubmed
pubmed-article:1695866pubmed:authorpubmed-author:LemosJ RJRlld:pubmed
pubmed-article:1695866pubmed:authorpubmed-author:StuenkelE LELlld:pubmed
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pubmed-article:1695866pubmed:pagination35-43lld:pubmed
pubmed-article:1695866pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:1695866pubmed:year1990lld:pubmed
pubmed-article:1695866pubmed:articleTitleSodium-activated cation channels in peptidergic nerve terminals.lld:pubmed
pubmed-article:1695866pubmed:affiliationBékésy Laboratory of Neurobiology, University of Hawaii, Honolulu 96822.lld:pubmed
pubmed-article:1695866pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1695866pubmed:publicationTypeIn Vitrolld:pubmed
pubmed-article:1695866pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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