pubmed-article:1695866 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:1695866 | lifeskim:mentions | umls-concept:C0027747 | lld:lifeskim |
pubmed-article:1695866 | lifeskim:mentions | umls-concept:C0007447 | lld:lifeskim |
pubmed-article:1695866 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
pubmed-article:1695866 | pubmed:issue | 1-2 | lld:pubmed |
pubmed-article:1695866 | pubmed:dateCreated | 1990-9-5 | lld:pubmed |
pubmed-article:1695866 | pubmed:abstractText | The patch-clamp technique was utilized to characterize a cation channel in peptidergic nerve terminals isolated from a crustacean neurosecretory system. The cation channel exhibits the unique property of being activated by [Na+]. Distributions of open times demonstrate the presence of two open states with a shift of the distribution from predominantly short open times at [Na+] less than or equal to 10 mM to a predominantly long open state at [Na+] greater than or equal to 40 mM. Desensitization of channel activation occurs on prolonged exposure to [Na+] greater than 40 mM. Open probability increased steeply with [Na+] but was largely independent of membrane potential. Comparison of current-voltage relationships from single dissociated terminals and from those in the intact system show no differences in conductance or selectivity with nearly equal permeability to Na+ and K+, and impermeability to Cs+, divalent cations and anions. Flickering block occurred with [Ca2+]i greater than 1 microM. We propose that Na-activated cation (NAC) channels are activated by Na+ entering during action potentials and provide a sustained depolarizing current that can help sustain repetitive or bursting activity and subsequent facilitation of secretion from these nerve terminals. | lld:pubmed |
pubmed-article:1695866 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1695866 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1695866 | pubmed:language | eng | lld:pubmed |
pubmed-article:1695866 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1695866 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:1695866 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1695866 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1695866 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1695866 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:1695866 | pubmed:month | May | lld:pubmed |
pubmed-article:1695866 | pubmed:issn | 0006-8993 | lld:pubmed |
pubmed-article:1695866 | pubmed:author | pubmed-author:CookeI MIM | lld:pubmed |
pubmed-article:1695866 | pubmed:author | pubmed-author:RubenPP | lld:pubmed |
pubmed-article:1695866 | pubmed:author | pubmed-author:LemosJ RJR | lld:pubmed |
pubmed-article:1695866 | pubmed:author | pubmed-author:StuenkelE LEL | lld:pubmed |
pubmed-article:1695866 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:1695866 | pubmed:day | 28 | lld:pubmed |
pubmed-article:1695866 | pubmed:volume | 517 | lld:pubmed |
pubmed-article:1695866 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:1695866 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:1695866 | pubmed:pagination | 35-43 | lld:pubmed |
pubmed-article:1695866 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
pubmed-article:1695866 | pubmed:meshHeading | pubmed-meshheading:1695866-... | lld:pubmed |
pubmed-article:1695866 | pubmed:meshHeading | pubmed-meshheading:1695866-... | lld:pubmed |
pubmed-article:1695866 | pubmed:meshHeading | pubmed-meshheading:1695866-... | lld:pubmed |
pubmed-article:1695866 | pubmed:meshHeading | pubmed-meshheading:1695866-... | lld:pubmed |
pubmed-article:1695866 | pubmed:meshHeading | pubmed-meshheading:1695866-... | lld:pubmed |
pubmed-article:1695866 | pubmed:meshHeading | pubmed-meshheading:1695866-... | lld:pubmed |
pubmed-article:1695866 | pubmed:meshHeading | pubmed-meshheading:1695866-... | lld:pubmed |
pubmed-article:1695866 | pubmed:year | 1990 | lld:pubmed |
pubmed-article:1695866 | pubmed:articleTitle | Sodium-activated cation channels in peptidergic nerve terminals. | lld:pubmed |
pubmed-article:1695866 | pubmed:affiliation | Békésy Laboratory of Neurobiology, University of Hawaii, Honolulu 96822. | lld:pubmed |
pubmed-article:1695866 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:1695866 | pubmed:publicationType | In Vitro | lld:pubmed |
pubmed-article:1695866 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:1695866 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
pubmed-article:1695866 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1695866 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1695866 | lld:pubmed |