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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2006-9-7
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pubmed:abstractText |
Recent clinical trials have indicated that lowering low-density lipoprotein cholesterol (LDL-C) levels below currently recommended targets results in favourable surrogate and clinical end points. The Treating to New Targets (TNT) study now confirms that aggressive cholesterol lowering to a mean LDL-C of 2.0 mmol/L with atorvastatin 80 mg daily, compared with the previous target of 2.5 mmol/L with atorvastatin 10 mg daily, results in improved clinical outcomes in high-risk patients with coronary artery disease. A lower LDL-C target of less than 2.0 mmol/L will present therapeutic challenges, because approximately only one-half of high-risk patients will achieve this target using monotherapy with the newer and more powerful statins. Furthermore, registry data show that one-half of these patients are not even achieving the current LDL-C target of 2.5 mmol/L. Causes of the care gap are discussed and possible remedies to achieve the new lower targets are suggested.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-10639539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-11558482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-12114036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-12324991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-14581310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-14996776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-15007110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-15249516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-15632889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-15685308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-15755765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-16214597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-16287954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-16310551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-16533939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-16731999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-17489153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-2877128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-5921755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-7566020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-7968073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-8801446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-9182651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-9576425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-9613910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16957800-9841303
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0828-282X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
835-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16957800-Canada,
pubmed-meshheading:16957800-Cholesterol, LDL,
pubmed-meshheading:16957800-Death, Sudden, Cardiac,
pubmed-meshheading:16957800-Dyslipidemias,
pubmed-meshheading:16957800-Heptanoic Acids,
pubmed-meshheading:16957800-Humans,
pubmed-meshheading:16957800-Hypolipidemic Agents,
pubmed-meshheading:16957800-Myocardial Infarction,
pubmed-meshheading:16957800-Pyrroles,
pubmed-meshheading:16957800-Randomized Controlled Trials as Topic,
pubmed-meshheading:16957800-Risk Assessment,
pubmed-meshheading:16957800-Stroke
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pubmed:year |
2006
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pubmed:articleTitle |
Lower is better: implications of the Treating to New Targets (TNT) study for Canadian patients.
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pubmed:affiliation |
Division of Cardiology, St. Michael's Hospital, Toronto, Ontario. fitchettd@smh.toronto.on.ca
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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