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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1990-8-28
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pubmed:abstractText |
Constitutive secretion of interleukin-6 (IL-6) has been proposed as a mechanism of transformation in multiple myeloma. We therefore studied 15 patients with this disease for rearrangements of the IL-6 and IL-6 receptor genes. Two patients with altered IL-6 genes were identified. Chromosome analysis revealed aberrations of chromosome 7, where the IL-6 gene resides, in only these two patients, but not in others without IL-6 rearrangements. In one of these patients, constitutive IL-6 m-RNA expression was observed. No alterations of IL-6 receptor genes were detected.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0887-6924
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
462-5
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:1695702-Base Sequence,
pubmed-meshheading:1695702-Blotting, Northern,
pubmed-meshheading:1695702-Blotting, Southern,
pubmed-meshheading:1695702-Bone Marrow,
pubmed-meshheading:1695702-Chromosomes, Human, Pair 7,
pubmed-meshheading:1695702-Deoxyribonuclease EcoRI,
pubmed-meshheading:1695702-Gene Rearrangement,
pubmed-meshheading:1695702-Humans,
pubmed-meshheading:1695702-Interleukin-6,
pubmed-meshheading:1695702-Leukemia, Plasma Cell,
pubmed-meshheading:1695702-Leukocytes, Mononuclear,
pubmed-meshheading:1695702-Metaphase,
pubmed-meshheading:1695702-Molecular Sequence Data,
pubmed-meshheading:1695702-Multiple Myeloma,
pubmed-meshheading:1695702-Polymerase Chain Reaction,
pubmed-meshheading:1695702-RNA,
pubmed-meshheading:1695702-RNA, Messenger,
pubmed-meshheading:1695702-Receptors, Immunologic,
pubmed-meshheading:1695702-Receptors, Interleukin-6
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pubmed:year |
1990
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pubmed:articleTitle |
The IL-6 gene but not the IL-6 receptor gene is occasionally rearranged in patients with multiple myeloma.
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pubmed:affiliation |
Department of Oncology/Hematology, University Hospital Eppendorf, Hamburg, F.R.G.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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