|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0021311,
umls-concept:C0085358,
umls-concept:C0185117,
umls-concept:C0220847,
umls-concept:C0332281,
umls-concept:C0392674,
umls-concept:C0400914,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C2698600,
umls-concept:C2911684
|
|
pubmed:issue |
22
|
|
pubmed:dateCreated |
2006-10-30
|
|
pubmed:abstractText |
Hepatitis C virus (HCV)-specific CD8 cell exhaustion may represent a mechanism of HCV persistence. The inhibitory receptor PD-1 has been reported to be up-regulated in exhausted CD8 cells. Therefore, we studied PD-1 expression longitudinally during acute HCV infection. Most HCV-specific CD8 cells expressed PD-1 at the time of acute illness, irrespective of the final outcome. PD-1 expression declined with the acquisition of a memory phenotype and recovery of an efficient CD8 cell function in resolving HCV infections, whereas high levels were maintained when HCV persisted and HCV-specific CD8 cells remained dysfunctional. Blocking PD-1/PDL-1 interaction with an anti-PDL-1 antibody improved the capacity of expansion of virus-specific CD8 cells.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956940-10790425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956940-11356962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956940-11714747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956940-12438568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956940-12538684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956940-12563257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956940-14625547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956940-15044705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956940-15140950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956940-15249675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956940-15598424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956940-15724249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956940-15879083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956940-16382236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956940-16500147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956940-16537621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16956940-16799989
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0022-538X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
80
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
11398-403
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:16956940-Antigens, CD,
pubmed-meshheading:16956940-Apoptosis Regulatory Proteins,
pubmed-meshheading:16956940-CD8-Positive T-Lymphocytes,
pubmed-meshheading:16956940-Flow Cytometry,
pubmed-meshheading:16956940-Hepacivirus,
pubmed-meshheading:16956940-Hepatitis C,
pubmed-meshheading:16956940-Humans,
pubmed-meshheading:16956940-Immunologic Memory,
pubmed-meshheading:16956940-Lymphocyte Subsets,
pubmed-meshheading:16956940-Programmed Cell Death 1 Receptor
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion.
|
|
pubmed:affiliation |
Laboratorio Immunopatologia Virale, Unit of Infectious Diseases and Hepatology, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci 14, 43100 Parma, Italy.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
