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pubmed-article:16956752pubmed:abstractTextIn the present study, increased levels of ANKHD1 mRNA and protein expression in leukemia cell lines are reported, as compared with normal hematopoietic cells. Furthermore, a higher expression of ANKHD1 mRNA was detected in primary acute leukemia samples than in normal hematopoietic cells (P=0.002). ANKHD1 was detected in the cytosolic and membrane fraction of cells and was co-immunoprecipitated with SHP2 in protein extracts of K562 and LNCaP cell lines. These findings suggest a role for ANKHD1 as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells.lld:pubmed
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pubmed-article:16956752pubmed:articleTitleANKHD1, ankyrin repeat and KH domain containing 1, is overexpressed in acute leukemias and is associated with SHP2 in K562 cells.lld:pubmed
pubmed-article:16956752pubmed:affiliationThe Hematology and Hemotherapy Center, Faculty of Medical Sciences, Department of Internal Medicine, State University of Campinas, São Paulo, Brazil.lld:pubmed
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