Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2006-9-25
pubmed:abstractText
In the present study, increased levels of ANKHD1 mRNA and protein expression in leukemia cell lines are reported, as compared with normal hematopoietic cells. Furthermore, a higher expression of ANKHD1 mRNA was detected in primary acute leukemia samples than in normal hematopoietic cells (P=0.002). ANKHD1 was detected in the cytosolic and membrane fraction of cells and was co-immunoprecipitated with SHP2 in protein extracts of K562 and LNCaP cell lines. These findings suggest a role for ANKHD1 as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:volume
1762
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
828-34
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:16956752-Acute Disease, pubmed-meshheading:16956752-Adolescent, pubmed-meshheading:16956752-Adult, pubmed-meshheading:16956752-Aged, pubmed-meshheading:16956752-Aged, 80 and over, pubmed-meshheading:16956752-Ankyrin Repeat, pubmed-meshheading:16956752-Case-Control Studies, pubmed-meshheading:16956752-Cell Line, Tumor, pubmed-meshheading:16956752-Cytoplasm, pubmed-meshheading:16956752-Gene Expression Regulation, Neoplastic, pubmed-meshheading:16956752-HL-60 Cells, pubmed-meshheading:16956752-Humans, pubmed-meshheading:16956752-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:16956752-K562 Cells, pubmed-meshheading:16956752-Leukemia, pubmed-meshheading:16956752-Middle Aged, pubmed-meshheading:16956752-Protein Tyrosine Phosphatase, Non-Receptor Type 11, pubmed-meshheading:16956752-Protein Tyrosine Phosphatases, pubmed-meshheading:16956752-Protein-Serine-Threonine Kinases, pubmed-meshheading:16956752-RNA, Messenger, pubmed-meshheading:16956752-Reverse Transcriptase Polymerase Chain Reaction
pubmed:year
2006
pubmed:articleTitle
ANKHD1, ankyrin repeat and KH domain containing 1, is overexpressed in acute leukemias and is associated with SHP2 in K562 cells.
pubmed:affiliation
The Hematology and Hemotherapy Center, Faculty of Medical Sciences, Department of Internal Medicine, State University of Campinas, São Paulo, Brazil.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't