rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
9
|
pubmed:dateCreated |
2006-9-25
|
pubmed:abstractText |
In the present study, increased levels of ANKHD1 mRNA and protein expression in leukemia cell lines are reported, as compared with normal hematopoietic cells. Furthermore, a higher expression of ANKHD1 mRNA was detected in primary acute leukemia samples than in normal hematopoietic cells (P=0.002). ANKHD1 was detected in the cytosolic and membrane fraction of cells and was co-immunoprecipitated with SHP2 in protein extracts of K562 and LNCaP cell lines. These findings suggest a role for ANKHD1 as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0006-3002
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
1762
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
828-34
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:16956752-Acute Disease,
pubmed-meshheading:16956752-Adolescent,
pubmed-meshheading:16956752-Adult,
pubmed-meshheading:16956752-Aged,
pubmed-meshheading:16956752-Aged, 80 and over,
pubmed-meshheading:16956752-Ankyrin Repeat,
pubmed-meshheading:16956752-Case-Control Studies,
pubmed-meshheading:16956752-Cell Line, Tumor,
pubmed-meshheading:16956752-Cytoplasm,
pubmed-meshheading:16956752-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16956752-HL-60 Cells,
pubmed-meshheading:16956752-Humans,
pubmed-meshheading:16956752-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:16956752-K562 Cells,
pubmed-meshheading:16956752-Leukemia,
pubmed-meshheading:16956752-Middle Aged,
pubmed-meshheading:16956752-Protein Tyrosine Phosphatase, Non-Receptor Type 11,
pubmed-meshheading:16956752-Protein Tyrosine Phosphatases,
pubmed-meshheading:16956752-Protein-Serine-Threonine Kinases,
pubmed-meshheading:16956752-RNA, Messenger,
pubmed-meshheading:16956752-Reverse Transcriptase Polymerase Chain Reaction
|
pubmed:year |
2006
|
pubmed:articleTitle |
ANKHD1, ankyrin repeat and KH domain containing 1, is overexpressed in acute leukemias and is associated with SHP2 in K562 cells.
|
pubmed:affiliation |
The Hematology and Hemotherapy Center, Faculty of Medical Sciences, Department of Internal Medicine, State University of Campinas, São Paulo, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|