Source:http://linkedlifedata.com/resource/pubmed/id/16956672
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
2006-10-30
|
| pubmed:abstractText |
The aim of this study was to investigate the clinical impact of reactivation of human herpes virus-6 (HHV-6) and HHV-7 infections in stem cell transplantation recipients, and to examine a possible increase in virulence of the two roseoloviruses when a reactivation of CMV (HHV-5) simultaneously occurs. For this purpose, quantitative real-time PCR systems were developed to assess the viral load of CMV, HHV-6, or HHV-7 in the plasma of haematopoetic stem cell recipients. One hundred and ninety-eight plasma samples from 37 patients who underwent allogeneic stem cell transplantation were tested for CMV, HHV-6, and HHV-7 by a 5'-exonuclease (TaqMan) quantitative real-time PCR. The CMV load obtained by the real-time PCR assay was compared retrospectively with results generated previously with a commercially available test (COBAS AMPLICOR CMV MONITOR Test, Roche). The results suggest that CMV and HHV-6 may be associated with post-transplantation end-organ disease, while HHV-7 reactivation had no impact on the patients included in this study. No evidence for a potential interaction of the roseoloviruses and CMV infections was found.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0166-0934
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
138
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
40-8
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| pubmed:meshHeading |
pubmed-meshheading:16956672-Adult,
pubmed-meshheading:16956672-Aged,
pubmed-meshheading:16956672-Cytomegalovirus,
pubmed-meshheading:16956672-Cytomegalovirus Infections,
pubmed-meshheading:16956672-Encephalitis, Viral,
pubmed-meshheading:16956672-Female,
pubmed-meshheading:16956672-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:16956672-Herpesviridae Infections,
pubmed-meshheading:16956672-Herpesvirus 6, Human,
pubmed-meshheading:16956672-Herpesvirus 7, Human,
pubmed-meshheading:16956672-Humans,
pubmed-meshheading:16956672-Male,
pubmed-meshheading:16956672-Middle Aged,
pubmed-meshheading:16956672-Polymerase Chain Reaction,
pubmed-meshheading:16956672-Roseolovirus Infections,
pubmed-meshheading:16956672-Transplantation, Homologous,
pubmed-meshheading:16956672-Viral Load,
pubmed-meshheading:16956672-Virus Activation
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Detection of beta-herpesviruses in allogenic stem cell recipients by quantitative real-time PCR.
|
| pubmed:affiliation |
Institut für Virologie, Medizinische Fakultät Carl Gustav Carus, Medizinisch-Theoretisches Zentrum, Fiedlerstrasse 42, 01307 Dresden, Germany.
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| pubmed:publicationType |
Journal Article,
Comparative Study
|