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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-12-5
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pubmed:abstractText |
We evaluated the effect of ebselen on human SH-SY5Y dopaminergic neuronal cells and determined whether ebselen, a glutathione peroxidase-mimetic, protected against MPTP-induced dopamine depletion in mice. Ebselen (10-100 microM) inhibited the proliferation of SH-SY5Y cells dose-dependently. Ebselen did not induce any behavioral changes and did not block MPTP-induced tremor and akinesia. Ebselen had no effect on the monoamine oxidase activity and did not protect against MPTP-induced dopamine depletion in striatum.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-Methyl-4-phenyl-1,2,3,6-tetrahydro...,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Azoles,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Peroxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Monoamine Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Organoselenium Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/ebselen
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
1118
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
251-4
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:16956591-1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine,
pubmed-meshheading:16956591-Animals,
pubmed-meshheading:16956591-Antioxidants,
pubmed-meshheading:16956591-Azoles,
pubmed-meshheading:16956591-Brain,
pubmed-meshheading:16956591-Cell Line, Tumor,
pubmed-meshheading:16956591-Cell Proliferation,
pubmed-meshheading:16956591-Disease Models, Animal,
pubmed-meshheading:16956591-Dopamine,
pubmed-meshheading:16956591-Dose-Response Relationship, Drug,
pubmed-meshheading:16956591-Glutathione Peroxidase,
pubmed-meshheading:16956591-Humans,
pubmed-meshheading:16956591-Mice,
pubmed-meshheading:16956591-Mice, Inbred C57BL,
pubmed-meshheading:16956591-Monoamine Oxidase,
pubmed-meshheading:16956591-Neurons,
pubmed-meshheading:16956591-Neuroprotective Agents,
pubmed-meshheading:16956591-Organoselenium Compounds,
pubmed-meshheading:16956591-Oxidative Stress,
pubmed-meshheading:16956591-Parkinsonian Disorders,
pubmed-meshheading:16956591-Treatment Outcome,
pubmed-meshheading:16956591-Tremor
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pubmed:year |
2006
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pubmed:articleTitle |
Ebselen effects on MPTP-induced neurotoxicity.
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pubmed:affiliation |
Department of Pharmacal Sciences, Division of Pharmacology and Toxicology, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA. dhanamu@auburn.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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