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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-9-7
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pubmed:abstractText |
The anti-inflammatory effect of adenosine is partially mediated via the A3 adenosine receptor (A3AR), a Gi protein associated cell surface receptor. The highly selective A3AR agonist, IB-MECA was earlier shown to prevent the clinical and pathological manifestations of arthritis in experimental animal models of collagen and adjuvant induced arthritis (AIA). In this study we tested the effect of IB-MECA on the prevention of bone resorption in AIA rats and looked at the molecular mechanism of action.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0392-856X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
400-6
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16956430-Adenosine,
pubmed-meshheading:16956430-Adenosine A3 Receptor Agonists,
pubmed-meshheading:16956430-Administration, Oral,
pubmed-meshheading:16956430-Animals,
pubmed-meshheading:16956430-Arthritis, Experimental,
pubmed-meshheading:16956430-Bone Density Conservation Agents,
pubmed-meshheading:16956430-Bone Resorption,
pubmed-meshheading:16956430-Bone and Bones,
pubmed-meshheading:16956430-Female,
pubmed-meshheading:16956430-Fibrosis,
pubmed-meshheading:16956430-Hindlimb,
pubmed-meshheading:16956430-Joints,
pubmed-meshheading:16956430-Rats,
pubmed-meshheading:16956430-Rats, Inbred Lew,
pubmed-meshheading:16956430-Receptor, Adenosine A3
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pubmed:articleTitle |
IB-MECA, an A3 adenosine receptor agonist prevents bone resorption in rats with adjuvant induced arthritis.
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pubmed:affiliation |
Can-Fite BioPharma Ltd., Kiryat-Matalon, Petah-Tikva, Israel.
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pubmed:publicationType |
Journal Article
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