rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
1990-8-30
|
pubmed:abstractText |
This is an analysis of the long-term follow-up data of 99 patients receiving HOAP-Bleo, IMVP-16 and PAC as salvage chemotherapy for refractory or relapsed intermediate or high grade non-Hodgkin's lymphomas. Most of the patients received HOAP-Bleo or PAC following failure of initial chemotherapy and IMVP-16 was used mainly for HOAP-Bleo failures. The longest follow-up time of the surviving patients was 108 months. Twenty-two and 29 per cent of the patients survived beyond 2 years following HOAP-Bleo and PAC respectively. The treatment outcome following IMVP-16 was worst with a 2-year survival of only 5 per cent, as it was used mainly following HOAP-Bleo failures. Although the prognosis of these refractory or relapsed cases are poor, salvage treatment is still worthwhile as a small proportion of these patients may have long-lasting remissions and occasional patients may be cured. Newer approaches such as autologous bone marrow transplantation should be compared with current salvage chemotherapy regimens.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0278-0232
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
8
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
133-40
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:1695607-Adult,
pubmed-meshheading:1695607-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:1695607-Bleomycin,
pubmed-meshheading:1695607-Cisplatin,
pubmed-meshheading:1695607-Cyclophosphamide,
pubmed-meshheading:1695607-Cytarabine,
pubmed-meshheading:1695607-Doxorubicin,
pubmed-meshheading:1695607-Female,
pubmed-meshheading:1695607-Follow-Up Studies,
pubmed-meshheading:1695607-Harringtonines,
pubmed-meshheading:1695607-Humans,
pubmed-meshheading:1695607-Ifosfamide,
pubmed-meshheading:1695607-Lymphoma, Non-Hodgkin,
pubmed-meshheading:1695607-Male,
pubmed-meshheading:1695607-Mesna,
pubmed-meshheading:1695607-Neoplasm Staging,
pubmed-meshheading:1695607-Prednisone,
pubmed-meshheading:1695607-Vincristine
|
pubmed:articleTitle |
Long-term follow-up of patients receiving salvage chemotherapy for intermediate and high grade non-Hodgkin's lymphomas.
|
pubmed:affiliation |
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|