Source:http://linkedlifedata.com/resource/pubmed/id/16955308
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2007-1-31
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| pubmed:abstractText |
The hepatitis C virus (HCV) non-structural (NS)5A protein is linked to interferon alpha resistance in vitro and higher numbers of NS5A amino acid (aa) variations in HCV 1a/b isolates are associated with virologic response to interferon alpha-based therapy in vivo. Here, we aimed to study NS5A aa variations in Indian patients undergoing interferon alpha/ribavirin treatment infected with HCV 3a. The NS5A region [aa 2194-2401, comprising interferon sensitivity determining region, protein kinase resource (PKR) binding domain, V3 region] was sequenced from pre-treatment sera of 24 patients with HCV 3a infection. Mean number and physicochemical properties of aa variations (conserved vs. non-conserved) were assessed. Additionally, published NS5A sequences [NS5A region (n = 61), PKR binding domain (n = 111)] of characterized HCV 3a isolates were analyzed. The mean number of NS5A aa variations was not correlated with treatment response in our cohort. When all available NS5A sequences were included, a higher number of non-conserved aa variations within PKR binding domain and an extended V3 region of NS5A was associated with virologic response (P = 0.004 and 0.05, respectively). Mutational analyses of a large number of NS5A sequences suggest, that a higher number of non-conserved aa variations within the PKR binding domain and the extended V3 region is correlated with virologic response in HCV 3a infected patients.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis C Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/NS-5 protein, hepatitis C virus,
http://linkedlifedata.com/resource/pubmed/chemical/Ribavirin,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Nonstructural Proteins
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0300-8584
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
196
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
11-21
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| pubmed:meshHeading |
pubmed-meshheading:16955308-Adult,
pubmed-meshheading:16955308-Amino Acid Sequence,
pubmed-meshheading:16955308-Antiviral Agents,
pubmed-meshheading:16955308-Cohort Studies,
pubmed-meshheading:16955308-Drug Resistance, Viral,
pubmed-meshheading:16955308-Female,
pubmed-meshheading:16955308-Hepacivirus,
pubmed-meshheading:16955308-Hepatitis C, Chronic,
pubmed-meshheading:16955308-Hepatitis C Antigens,
pubmed-meshheading:16955308-Humans,
pubmed-meshheading:16955308-India,
pubmed-meshheading:16955308-Interferon-alpha,
pubmed-meshheading:16955308-Male,
pubmed-meshheading:16955308-Middle Aged,
pubmed-meshheading:16955308-Molecular Sequence Data,
pubmed-meshheading:16955308-Mutation,
pubmed-meshheading:16955308-Protein Structure, Secondary,
pubmed-meshheading:16955308-Ribavirin,
pubmed-meshheading:16955308-Sequence Alignment,
pubmed-meshheading:16955308-Viral Nonstructural Proteins
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| pubmed:year |
2007
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| pubmed:articleTitle |
The hepatitis C virus NS5A protein and response to interferon alpha: mutational analyses in patients with chronic HCV genotype 3a infection from India.
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| pubmed:affiliation |
Department of Gastroenterology, G.B. Pant Hospital, University of Delhi, New Delhi, India.
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| pubmed:publicationType |
Journal Article
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