| pubmed-article:1695412 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1695412 | lifeskim:mentions | umls-concept:C0014049 | lld:lifeskim |
| pubmed-article:1695412 | lifeskim:mentions | umls-concept:C0017968 | lld:lifeskim |
| pubmed-article:1695412 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:1695412 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:1695412 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:1695412 | lifeskim:mentions | umls-concept:C1446680 | lld:lifeskim |
| pubmed-article:1695412 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:1695412 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:1695412 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1695412 | pubmed:dateCreated | 1990-8-21 | lld:pubmed |
| pubmed-article:1695412 | pubmed:abstractText | Stable neutralization (N) escape variants of Venezuelan equine encephalitis (VEE) virus were selected by anti-E2 glycoprotein monoclonal antibodies (MAbs) that neutralize viral infectivity, block viral hemagglutination, and passively protect mice. The nucleotide sequence of the E1, E2, and E3 genes of four variants revealed a clustering of single mutations in a domain spanning E2-182 to E2-207. The conformation of this short linear sequence affects antigenicity in the N domain because reduction and alkylation of virus disrupted binding of some E2 neutralizing MAbs. Serologic evidence for interaction of E2 epitopes also was obtained. Mutations in the N domain of VEE virus did not alter the kinetics of binding to Vero cells. They did, in some cases, produce attenuation of virulence in mice. | lld:pubmed |
| pubmed-article:1695412 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1695412 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1695412 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1695412 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1695412 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1695412 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:1695412 | pubmed:author | pubmed-author:URATAGG | lld:pubmed |
| pubmed-article:1695412 | pubmed:author | pubmed-author:JohnsonB JBJ | lld:pubmed |
| pubmed-article:1695412 | pubmed:author | pubmed-author:RoehrigJ TJT | lld:pubmed |
| pubmed-article:1695412 | pubmed:author | pubmed-author:BrubakerJ RJR | lld:pubmed |
| pubmed-article:1695412 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1695412 | pubmed:volume | 177 | lld:pubmed |
| pubmed-article:1695412 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1695412 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1695412 | pubmed:pagination | 676-83 | lld:pubmed |
| pubmed-article:1695412 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:1695412 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1695412 | pubmed:articleTitle | Variants of Venezuelan equine encephalitis virus that resist neutralization define a domain of the E2 glycoprotein. | lld:pubmed |
| pubmed-article:1695412 | pubmed:affiliation | Division of Vector-Borne Viral Diseases, Centers for Disease Control, Fort Collins, Colorado 80522. | lld:pubmed |
| pubmed-article:1695412 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1695412 | pubmed:publicationType | Comparative Study | lld:pubmed |
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