Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
36
pubmed:dateCreated
2006-9-6
pubmed:abstractText
QS-21 is one of the most promising new adjuvants for immune response potentiation and dose-sparing in vaccine therapy given its exceedingly high level of potency and its favorable toxicity profile. Melanoma, breast cancer, small cell lung cancer, prostate cancer, HIV-1, and malaria are among the numerous maladies targeted in more than 80 recent and ongoing vaccine therapy clinical trials involving QS-21 as a critical adjuvant component for immune response augmentation. QS-21 is a natural product immunostimulatory adjuvant, eliciting both T-cell- and antibody-mediated immune responses with microgram doses. Herein is reported the synthesis of QS-21A(api) in a highly modular strategy, applying novel glycosylation methodologies to a convergent construction of the potent saponin immunostimulant. The chemical synthesis of QS-21 offers unique opportunities to probe its mode of biological action through the preparation of otherwise unattainable nonnatural saponin analogues.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16953631-10318949, http://linkedlifedata.com/resource/pubmed/commentcorrection/16953631-11027818, http://linkedlifedata.com/resource/pubmed/commentcorrection/16953631-11228380, http://linkedlifedata.com/resource/pubmed/commentcorrection/16953631-11248068, http://linkedlifedata.com/resource/pubmed/commentcorrection/16953631-11405715, http://linkedlifedata.com/resource/pubmed/commentcorrection/16953631-11448206, http://linkedlifedata.com/resource/pubmed/commentcorrection/16953631-11559191, http://linkedlifedata.com/resource/pubmed/commentcorrection/16953631-12071743, http://linkedlifedata.com/resource/pubmed/commentcorrection/16953631-14614001, http://linkedlifedata.com/resource/pubmed/commentcorrection/16953631-14871967, http://linkedlifedata.com/resource/pubmed/commentcorrection/16953631-15063565, http://linkedlifedata.com/resource/pubmed/commentcorrection/16953631-15755124, http://linkedlifedata.com/resource/pubmed/commentcorrection/16953631-15989326, http://linkedlifedata.com/resource/pubmed/commentcorrection/16953631-1987271, http://linkedlifedata.com/resource/pubmed/commentcorrection/16953631-4365900, http://linkedlifedata.com/resource/pubmed/commentcorrection/16953631-7942254, http://linkedlifedata.com/resource/pubmed/commentcorrection/16953631-8581890, http://linkedlifedata.com/resource/pubmed/commentcorrection/16953631-8853958, http://linkedlifedata.com/resource/pubmed/commentcorrection/16953631-8926578, http://linkedlifedata.com/resource/pubmed/commentcorrection/16953631-8934649, http://linkedlifedata.com/resource/pubmed/commentcorrection/16953631-9261947
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0002-7863
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
128
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11906-15
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Synthetic studies of complex immunostimulants from Quillaja saponaria: synthesis of the potent clinical immunoadjuvant QS-21Aapi.
pubmed:affiliation
Department of Chemistry, University of Illinois, Urbana, Illinois 61801, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural