Linked Life Data

16952056

Source:http://linkedlifedata.com/resource/pubmed/id/16952056

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
2006-11-9
pubmed:abstractText
Perlecan is a large multi-domain extracellular matrix proteoglycan that plays a crucial role in tissue development and organogenesis. In vertebrates, perlecan functions in a diverse range of developmental and biological processes, from the establishment of cartilage to the regulation of wound healing. How can a single molecule modulate such a wide variety of processes? We suggest that perlecan employs the same basic mechanism, based on interactions with growth factors, morphogens and matrix proteins, to regulate each of these processes and that the local extracellular environment determines the function of perlecan and consequently its downstream effects on the structure and function of the organ. We discuss this hypothesis in relation to its role in three major vertebrate developmental processes: angiogenesis, chondrogenesis and endochondral ossification.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1420-682X
pubmed:author
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2435-45
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Perlecan: how does one molecule do so many things?
pubmed:affiliation
Graduate School of Biomedical Engineering, University of New South Wales, Level 5, Samuels Bldg, Kensington, New South Wales, 2052, Australia.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't