16951223

Source:http://linkedlifedata.com/resource/pubmed/id/16951223

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0004083, umls-concept:C0017932, umls-concept:C0027651, umls-concept:C0086418, umls-concept:C0346647, umls-concept:C0521447, umls-concept:C1150423, umls-concept:C2248595
pubmed:issue	17
pubmed:dateCreated	2006-9-4
pubmed:abstractText	We have shown recently that glycogen synthase kinase-3 (GSK-3) beta regulates nuclear factor-kappaB (NF-kappaB)-mediated pancreatic cancer cell survival and proliferation in vitro. Our objective was to determine the localization of GSK-3beta in pancreatic cancer cells and assess the antitumor effect of GSK-3 inhibition in vivo to improve our understanding of the mechanism by which GSK-3beta affects NF-kappaB activity in pancreatic cancer.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/P20 CA102701-010003, http://linkedlifedata.com/resource/pubmed/grant/P50 CA102701, http://linkedlifedata.com/resource/pubmed/grant/P50 CA102701-04
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-10195897, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-10202930, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-10894547, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-12065308, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-12615961, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-12663502, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-12928438, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-1333807, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-14520463, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-15292388, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-15361837, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-15380510, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-15466414, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-15652748, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-15723355, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-15781615, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-16023596, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-16043125, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-16166627, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-16407823, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-6828386, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-7603567, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-8588920, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-9072970, http://linkedlifedata.com/resource/pubmed/commentcorrection/16951223-9918209
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9502500
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinase 3, http://linkedlifedata.com/resource/pubmed/chemical/N-(4-methoxybenzyl)-N'-(5-nitro-1,3-..., http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B, http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles, http://linkedlifedata.com/resource/pubmed/chemical/Urea, http://linkedlifedata.com/resource/pubmed/chemical/glycogen synthase kinase 3 beta
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	1078-0432
pubmed:author	pubmed-author:BilimVladimir NVN, pubmed-author:BilladeauDaniel DDD, pubmed-author:ChariSuresh TST, pubmed-author:Fernandez-ZapicoMartin EME, pubmed-author:OugolkovAndrei VAV, pubmed-author:SmyrkThomas CTC
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	12
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	5074-81
pubmed:dateRevised	2011-11-2
pubmed:meshHeading	pubmed-meshheading:16951223-Adenocarcinoma, pubmed-meshheading:16951223-Animals, pubmed-meshheading:16951223-Apoptosis, pubmed-meshheading:16951223-Cell Differentiation, pubmed-meshheading:16951223-Cell Line, Tumor, pubmed-meshheading:16951223-Cell Nucleus, pubmed-meshheading:16951223-Cell Proliferation, pubmed-meshheading:16951223-Female, pubmed-meshheading:16951223-Glycogen Synthase Kinase 3, pubmed-meshheading:16951223-Humans, pubmed-meshheading:16951223-Male, pubmed-meshheading:16951223-Mice, pubmed-meshheading:16951223-Mice, Nude, pubmed-meshheading:16951223-Middle Aged, pubmed-meshheading:16951223-NF-kappa B, pubmed-meshheading:16951223-Pancreatic Neoplasms, pubmed-meshheading:16951223-Structure-Activity Relationship, pubmed-meshheading:16951223-Survival Rate, pubmed-meshheading:16951223-Thiazoles, pubmed-meshheading:16951223-Transplantation, Heterologous, pubmed-meshheading:16951223-Urea, pubmed-meshheading:16951223-Xenograft Model Antitumor Assays
pubmed:year	2006
pubmed:articleTitle	Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation.
pubmed:affiliation	Division of Oncology Research, Gastrointestinal Unit, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural