Linked Life Data

16949772

Source:http://linkedlifedata.com/resource/pubmed/id/16949772

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2006-10-23
pubmed:abstractText
Comparison of closely related genome sequences can provide a clue as to how macroscopic genome polymorphisms were formed through various events of recombination. However, this approach has been limited to relatively simple polymorphisms such as insertion, deletion and inversion. In the present study, we tried to extend this approach to more complex genome polymorphisms that were observed when four genome sequences of bacterial genus Neisseria were compared. The first polymorphism was an apparent translocation (ab-cd to cd-ba; a region 'ab' was translocated). The second one was a re-ordering of adjacent regions (ab-cd-ef-gh to ef-cd-ab-gh; ab, cd and ef were in reverse order). The third one was a translocation of two adjacent regions with permutation of their order (ab-cd to cd-ab elsewhere in the genome). The fourth one was a genome-wide inversion associated with a genome-specific insertion into the joints (-ab-cd- to -y-ba-x-cd-). We were able to explain their formation by only a few steps of plausible events of recombination that involved linked IS copies and prophages. Our approach would help to reconstruct a history of apparently complex genome polymorphisms in any forms of organisms and to understand genome rearrangements in the natural environments in non-model organisms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0378-1119
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
383
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
52-63
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
How genomes rearrange: genome comparison within bacteria Neisseria suggests roles for mobile elements in formation of complex genome polymorphisms.
pubmed:affiliation
Department of Medical Genome Sciences, Graduate School of Frontier Science, the University of Tokyo, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't