Linked Life Data

16948212

Source:http://linkedlifedata.com/resource/pubmed/id/16948212

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2006-9-4
pubmed:abstractText
There is an increasing scientific concern that organochlorine compounds, recognized as environmental pollutants, may cause estrogen-related disorders. One of the main hypotheses is that organochlorines can act through their estrogenic or anti-estrogenic properties. Many endocrine diseases can be concerned by the pathogenic role on environmental residues in their promotion. The carcinogenic potential of environmental xenoestrogens on breast cancer is a matter of controversy. In Europe, despite their prohibition since the 70's, residues persist in soil and rivers, resulting in a widespread contamination of the general population. Our results suggest that environmental exposure to p,p'-DDE, HCB or PCBS may contribute to multifactorial pathogenesis of breast cancer. Male infertility is also a matter of concern. Our data suggest that male infertility can be associated with exposure of the mothers to p,p'-DDE, and that deleterious effects are probably restricted to intra-uterine life. Early or precocious puberty in children adopted from developing countries where organochlorines are still used is frequently reported. A possible relationship with exposure to DDT is suggested. There are two possible pathways to account for precocious puberty following chronic exposure to estrogenic related compounds: weak stimulation of estrogen sensitive tissues or removal in Belgium of the suppressing effects of estrogens on gonadotrophins, suppressing effect that was due to exposure in the origin country.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0377-8231
pubmed:author
pubmed:issnType
Print
pubmed:volume
161
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
116-24; discussion 124-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
[Effects of environmental pollutants on hormone disturbances].
pubmed:affiliation
Service de Toxicologie Clinique et de Toxicologie Médico-légale, CHU de Liège.
pubmed:publicationType
Journal Article, English Abstract