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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1990-8-16
|
| pubmed:abstractText |
We have designed a hammerhead-type RNA system which consists of three RNA fragments for normal and modified complexes which contain a non-cleavable substrate with 2'-O-methylcytidine and a guanosine-to-inosine replaced enzyme. Examination of the RNA-cleaving activity and conformational properties of the complexes suggests that the 2-amino group of a conserved guanosine residue in the loop region plays an important role for maintaining both the activity and loop conformation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0014-5793
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
2
|
| pubmed:volume |
267
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
150-2
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:1694789-Base Sequence,
pubmed-meshheading:1694789-Chemical Phenomena,
pubmed-meshheading:1694789-Chemistry,
pubmed-meshheading:1694789-Guanosine,
pubmed-meshheading:1694789-Magnetic Resonance Spectroscopy,
pubmed-meshheading:1694789-Molecular Sequence Data,
pubmed-meshheading:1694789-Nucleic Acid Conformation,
pubmed-meshheading:1694789-RNA,
pubmed-meshheading:1694789-RNA, Catalytic,
pubmed-meshheading:1694789-RNA, Ribosomal
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
The role of a conserved guanosine residue in the hammerhead-type RNA enzyme.
|
| pubmed:affiliation |
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
|
| pubmed:publicationType |
Journal Article
|