Linked Life Data

1694654

Source:http://linkedlifedata.com/resource/pubmed/id/1694654

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1990-8-6
pubmed:abstractText
We examined the immunohistochemical profile of 21 granular cell tumors (GCTs) and a single clinically malignant GCT using a panel of commercially available antibodies. All cases showed diffuse cytoplasmic and nuclear staining for S100 protein. Fourteen cases stained for myelin basic protein, Leu-7, or both. Immunostains for neurofilament protein and glial fibrillary acidic protein were negative in all cases. Stains for cathepsin B and alpha 1-antichymotrypsin were positive in 21 and 15 cases, respectively. Cathepsin-B reactivity may reflect autodigestion of myelin, while the presence of alpha 1-antichymotrypsin is less specific and may be related to cellular production of this product or to nonspecific uptake of alpha 1-antichymotrypsin in serum during the formation of phagolysosomes. All tumors expressed vimentin, often in a distinctive peripheral cytoplasmic pattern. Focal desmin staining was seen in three separate specimens from the patients with the malignant GCT, but this tumor also expressed S100 protein, myelin basic protein, and Leu-7 and did not stain for muscle-specific actin. The desmin reactivity in this single case probably represents non-specific staining rather than myogenous differentiation, since the reactivity to other nerve sheath markers shows histogenetic similarity with the benign GCTs. These findings support a Schwann cell origin for nongingival GCTs and illustrate a useful panel of commercially available antibodies to diagnose these distinctive tumors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0003-9985
pubmed:author
pubmed:issnType
Print
pubmed:volume
114
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
692-6
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Granular cell tumor. Immunohistochemical analysis of 21 benign tumors and one malignant tumor.
pubmed:affiliation
Division of Surgical Pathology, University of Alabama, Birmingham.
pubmed:publicationType
Journal Article