Linked Life Data

16946534

Source:http://linkedlifedata.com/resource/pubmed/id/16946534

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2006-9-1
pubmed:abstractText
Stmerin D, a pressurized metered dose inhaler (MDI) for treatment of asthma, contains CFCs (chlorofluorocarbons) as a propellant. For the CFC replacement study, two formulations were prepared using hydrofluoroalkanes (HFA-134a and HFA-227) and the effect of storage on the spray performance was investigated under accelerated stress conditions. Drug stability, moisture content and spray performances such as the emitted dose uniformity and aerodynamic particle size distribution were evaluated. Drug content did not change after 3 months storage at 40 degrees C/75% RH. However, the emitted dose uniformity varied and the respirable fraction (RF) was reduced remarkably. While stored at 40 degrees C/ambient for 3 months, no change was observed in either drug content or spray performances. This study clarified that the moisture content in the canister played an important role on the spray performance, and it changed not only the emitted dose uniformity but also the particle size distribution. Consequently, in order to improve the stability of the spray performance of aerosol prepared with HFAs, moisture permeation into the canister must be controlled.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0009-2363
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1276-80
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Effect of the moisture content in aerosol on the spray performance of Stmerin D HFA preparations.
pubmed:affiliation
Pharmaceutical Research and Technology Laboratories, Astellas Pharma Inc., 2-1-6 Kashima, Osaka 532-8514 Japan. saburo.murata@jp.astellas.com
pubmed:publicationType
Journal Article