Linked Life Data

16946086

Source:http://linkedlifedata.com/resource/pubmed/id/16946086

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-2-2
pubmed:abstractText
Chronic heavy alcohol consumption alters cardiac structure and function. Controversies remain as to whether hearts from females respond to the chronic ethanol intake in a manner analogous to males. In particular, sex differences in the myocardial response to chronic alcohol consumption remain unresolved at the molecular level. The purpose of the present set of experiments was to determine whether alterations in cardiac structure and protein metabolism show sexual dimorphism following chronic alcohol consumption for 26 wk. In control animals, hearts from female rats showed lowered heart weights and had thinner ventricular walls compared with males. The smaller heart size was associated with a lower protein content that occurred in part from a reduced rate of protein synthesis. Chronic alcohol consumption in males, but not in females, caused a thinning of the ventricular wall and intraventricular septum, as assessed by echocardiography, correlating with the loss of heart mass. The alterations in cardiac size occurred, in part, through a lowering of the protein content secondary to a diminished rate of protein synthesis. The decreased rate of protein synthesis appeared related to a reduced assembly of active eukaryotic initiation factor (eIF)4G.eIF4E complex secondary to both a diminished phosphorylation of eIF4G and increased formation of inactive 4Ebinding protein (4EBP1).eIF4E complex. The latter effects occurred as a result of decreased phosphorylation of 4EBP1. None of these ethanol-induced alterations in hearts from males were observed in hearts from females. These data suggest that chronic alcohol-induced impairments in myocardial protein synthesis results, in part, from marked decreases in eIF4E.eIF4G complex formation in males. The failure of female rats consuming ethanol to show structural changes appears related to the inability of ethanol to affect the regulation protein synthesis to the same extent as their male counterparts.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0363-6119
pubmed:author
pubmed:issnType
Print
pubmed:volume
292
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R778-87
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed-meshheading:16946086-Animals, pubmed-meshheading:16946086-Blotting, Western, pubmed-meshheading:16946086-Central Nervous System Depressants, pubmed-meshheading:16946086-Contractile Proteins, pubmed-meshheading:16946086-Diet, pubmed-meshheading:16946086-Echocardiography, pubmed-meshheading:16946086-Ethanol, pubmed-meshheading:16946086-Eukaryotic Initiation Factor-4E, pubmed-meshheading:16946086-Eukaryotic Initiation Factor-4G, pubmed-meshheading:16946086-Female, pubmed-meshheading:16946086-Heart, pubmed-meshheading:16946086-Kinetics, pubmed-meshheading:16946086-Male, pubmed-meshheading:16946086-Myocardium, pubmed-meshheading:16946086-Organ Size, pubmed-meshheading:16946086-Phosphorylation, pubmed-meshheading:16946086-Rats, pubmed-meshheading:16946086-Rats, Sprague-Dawley, pubmed-meshheading:16946086-Sex Characteristics
pubmed:year
2007
pubmed:articleTitle
Sex-dependent differences in the regulation of myocardial protein synthesis following long-term ethanol consumption.
pubmed:affiliation
Department of Cellular and Molecular Physiology, Penn State University College of Medicine, H166, 500 University Dr., Hershey, PA 17033, USA. tvary@psu.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural