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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2006-9-1
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pubmed:abstractText |
Mice deficient in 14-3-3epsilon exhibit abnormal neuronal migration and die perinatally. We report here the first large-scale analysis of 14-3-3 interacting partners from primary animal tissue, identifying from embryonic murine brain 163 14-3-3epsilon interacting proteins and 85 phosphorylation sites on these proteins. Phosphorylation of the deubiquitinating enzyme USP8 at serine 680 was found essential for its interaction with 14-3-3epsilon and for maintaining USP8 in the cytosol.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1535-3893
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2372-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16944949-14-3-3 Proteins,
pubmed-meshheading:16944949-Amino Acid Sequence,
pubmed-meshheading:16944949-Animals,
pubmed-meshheading:16944949-Binding Sites,
pubmed-meshheading:16944949-Brain,
pubmed-meshheading:16944949-COS Cells,
pubmed-meshheading:16944949-Cercopithecus aethiops,
pubmed-meshheading:16944949-Endopeptidases,
pubmed-meshheading:16944949-Endosomal Sorting Complexes Required for Transport,
pubmed-meshheading:16944949-Mass Spectrometry,
pubmed-meshheading:16944949-Mice,
pubmed-meshheading:16944949-Microscopy, Fluorescence,
pubmed-meshheading:16944949-Molecular Sequence Data,
pubmed-meshheading:16944949-Phosphorylation,
pubmed-meshheading:16944949-Ubiquitin Thiolesterase
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pubmed:year |
2006
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pubmed:articleTitle |
Identification of 14-3-3epsilon substrates from embryonic murine brain.
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pubmed:affiliation |
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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