Linked Life Data

16944422

Source:http://linkedlifedata.com/resource/pubmed/id/16944422

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-8-31
pubmed:abstractText
Integrins are the major receptors mediating adhesion to the extracellular matrix. Following ligand binding, conformational changes of integrins induce the recruitment of multiple signaling and scaffolding proteins that connect integrin tails to the actin cytoskeleton and permit activation of signaling pathways regulating cell proliferation, apoptosis, differentiation, and migration. In the ovary, extracellular matrix components present in the follicular basement membrane, around follicular cells, and in the follicular fluid participate in the regulation of follicular development, and a role of integrins in this process is strongly suggested. We discuss available data on integrin expression in ovary, integrin function in granulosa cells, and the possible involvement of integrins in follicular growth, atresia, and luteinization. We also discuss the potential role of oocyte integrins as receptors for sperm ADAMs (a disintegrin and metalloproteinase) in fertilization and the cooperation of integrins with proteinases in regulating proliferation, adhesion, migration, and invasion of ovarian surface epithelium cells in ovarian tumor development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1526-8004
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
251-61
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Integrins in the ovary.
pubmed:affiliation
Physiologie de la Reproduction et des Comportements, INRA-CNRS-Université de Tours-Haras Nationaux, INRA Nouzilly, France. monniaux@tours.inra.fr
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural