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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2006-9-19
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pubmed:abstractText |
Brazilian patients with benign prostatic hyperplasia were randomised in a 12-week, double-blind, double-dummy study to receive doxazosin gastrointestinal therapeutic system (GITS) 4 mg q.i.d. (n = 82) or tamsulosin 0.4 q.i.d. (n = 83). Primary endpoints were the absolute and percentage change from baseline in symptoms measured by International Prostate Symptom Score (IPSS). Secondary endpoints included IPSS, quality-of-life (QOL) question from the IPSS, and questions 6 and 7 of the Sexual Function Abbreviated Questionnaire (SFAQ) at weeks 4 and 12. Doxazosin GITS and tamsulosin improved IPSS with no significant differences between groups at week 12. During weeks 4-8, tamsulosin-treated patients demonstrated a slower improvement (p < 0.001) in IPSS than doxazosin GITS-treated patients. The proportion of satisfied patients was observed earlier with doxazosin GITS (p = 0.006) vs. tamsulosin. At week 12, the proportion of patients with little or no difficulty at ejaculation (Q6 of SFAQ) was higher in the doxazosin GITS group (p = 0.019). Both treatments were well tolerated.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942589-10364649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942589-10594469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942589-11025377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942589-11074198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942589-11167641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942589-11248621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942589-12614248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942589-12699128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942589-12800456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942589-14681504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942589-14767264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942589-14994963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942589-15049986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942589-6206240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942589-7539853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942589-7551841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942589-8647139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942589-9143856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16942589-9609624
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1368-5031
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pubmed:author |
pubmed-author:BerteroEE,
pubmed-author:CairoliC E DCE,
pubmed-author:DA RosC TCT,
pubmed-author:DamiãoRR,
pubmed-author:Doxazosin and Tamsulosin Study Investigator Group,
pubmed-author:KoffW JWJ,
pubmed-author:MesquitaFF,
pubmed-author:PinheiroG EGE,
pubmed-author:PompeoA C LAC,
pubmed-author:RosenblattCC,
pubmed-author:WroclawskiE RER
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1172-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16942589-Adrenergic alpha-Antagonists,
pubmed-meshheading:16942589-Aged,
pubmed-meshheading:16942589-Delayed-Action Preparations,
pubmed-meshheading:16942589-Double-Blind Method,
pubmed-meshheading:16942589-Doxazosin,
pubmed-meshheading:16942589-Drug Therapy, Combination,
pubmed-meshheading:16942589-Humans,
pubmed-meshheading:16942589-Male,
pubmed-meshheading:16942589-Middle Aged,
pubmed-meshheading:16942589-Patient Satisfaction,
pubmed-meshheading:16942589-Prostatic Hyperplasia,
pubmed-meshheading:16942589-Quality of Life,
pubmed-meshheading:16942589-Sulfonamides,
pubmed-meshheading:16942589-Treatment Outcome
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pubmed:year |
2006
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pubmed:articleTitle |
A randomised, double-blind study comparing the efficacy and tolerability of controlled-release doxazosin and tamsulosin in the treatment of benign prostatic hyperplasia in Brazil.
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pubmed:affiliation |
IMEG, São Paulo, Brazil. pompeuro@uol.com.br
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pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial,
Multicenter Study
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