| pubmed-article:1694243 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1694243 | lifeskim:mentions | umls-concept:C0013227 | lld:lifeskim |
| pubmed-article:1694243 | lifeskim:mentions | umls-concept:C0004927 | lld:lifeskim |
| pubmed-article:1694243 | lifeskim:mentions | umls-concept:C0006685 | lld:lifeskim |
| pubmed-article:1694243 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:1694243 | lifeskim:mentions | umls-concept:C0205464 | lld:lifeskim |
| pubmed-article:1694243 | lifeskim:mentions | umls-concept:C1555903 | lld:lifeskim |
| pubmed-article:1694243 | lifeskim:mentions | umls-concept:C0220821 | lld:lifeskim |
| pubmed-article:1694243 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1694243 | pubmed:dateCreated | 1990-7-31 | lld:pubmed |
| pubmed-article:1694243 | pubmed:abstractText | The behavioral (deficits in motor function in mice), neurochemical (affinity for mouse brain membrane dihydropyridine receptors, effects on neurotransmitter/metabolite levels in mice) and pharmacologic (effect on the contractile activity of guinea pig ileal longitudinal smooth muscle) properties of the calcium channel activators (+/-)-BAY K 8644, (+/-)-202-791 (and their corresponding channel activating and antagonist enantiomers) and CGP-28392 were investigated and compared. The calcium channel activating enantiomers (-)-S-BAY K 8644, (+)-S-202-791 and (+/-)-BAY K 8644, (+/-)-202-791 and CGP-28392 produced a dose-dependent impairment of rotarod ability and decreases in motor activity in mice with the following order of potency: (-)-S-BAY K 8644 greater than (+/-)-BAY K 8644 much greater than (+)-S-202-791 greater than (+/-)-202-791 = CGP-28392. The calcium channel antagonists (+)-R-BAY K 8644 and (-)-R-202-791 were behaviorally inactive but blocked the behavioral effects of (-)-S-BAY K 8644. The binding of dihydropyridine calcium channel activator and antagonist enantiomers to mouse brain membranes was described by both one and two site models. (-)-S-BAY K 8644, (+/-)-BAY K 8644, (+)-S-202-791 and CGP-28392 produced contractions in partially depolarized (15 mM K+) strips of guinea pig ileal longitudinal smooth muscle which differed in the degree of maximum contraction obtained. (+)-R-BAY K 8644 and (-)-R-202-791 inhibited potassium-induced contractions (80 mM K+) in guinea pig ileal longitudinal smooth muscle.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:1694243 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1694243 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1694243 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1694243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1694243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1694243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1694243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1694243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1694243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1694243 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1694243 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1694243 | pubmed:issn | 0022-3565 | lld:pubmed |
| pubmed-article:1694243 | pubmed:author | pubmed-author:TriggleC RCR | lld:pubmed |
| pubmed-article:1694243 | pubmed:author | pubmed-author:CampbellNN | lld:pubmed |
| pubmed-article:1694243 | pubmed:author | pubmed-author:McCOYO ROR | lld:pubmed |
| pubmed-article:1694243 | pubmed:author | pubmed-author:CrowleyMM | lld:pubmed |
| pubmed-article:1694243 | pubmed:author | pubmed-author:BolgerG TGT | lld:pubmed |
| pubmed-article:1694243 | pubmed:author | pubmed-author:O'NeillS KSK | lld:pubmed |
| pubmed-article:1694243 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1694243 | pubmed:volume | 253 | lld:pubmed |
| pubmed-article:1694243 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1694243 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1694243 | pubmed:pagination | 905-12 | lld:pubmed |
| pubmed-article:1694243 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1694243 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1694243 | pubmed:articleTitle | Comparative behavioral, neurochemical and pharmacological activities of dihydropyridine calcium channel activating drugs. | lld:pubmed |
| pubmed-article:1694243 | pubmed:affiliation | Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada. | lld:pubmed |
| pubmed-article:1694243 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1694243 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1694243 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1694243 | lld:pubmed |
