Linked Life Data

1694243

Source:http://linkedlifedata.com/resource/pubmed/id/1694243

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-7-31
pubmed:abstractText
The behavioral (deficits in motor function in mice), neurochemical (affinity for mouse brain membrane dihydropyridine receptors, effects on neurotransmitter/metabolite levels in mice) and pharmacologic (effect on the contractile activity of guinea pig ileal longitudinal smooth muscle) properties of the calcium channel activators (+/-)-BAY K 8644, (+/-)-202-791 (and their corresponding channel activating and antagonist enantiomers) and CGP-28392 were investigated and compared. The calcium channel activating enantiomers (-)-S-BAY K 8644, (+)-S-202-791 and (+/-)-BAY K 8644, (+/-)-202-791 and CGP-28392 produced a dose-dependent impairment of rotarod ability and decreases in motor activity in mice with the following order of potency: (-)-S-BAY K 8644 greater than (+/-)-BAY K 8644 much greater than (+)-S-202-791 greater than (+/-)-202-791 = CGP-28392. The calcium channel antagonists (+)-R-BAY K 8644 and (-)-R-202-791 were behaviorally inactive but blocked the behavioral effects of (-)-S-BAY K 8644. The binding of dihydropyridine calcium channel activator and antagonist enantiomers to mouse brain membranes was described by both one and two site models. (-)-S-BAY K 8644, (+/-)-BAY K 8644, (+)-S-202-791 and CGP-28392 produced contractions in partially depolarized (15 mM K+) strips of guinea pig ileal longitudinal smooth muscle which differed in the degree of maximum contraction obtained. (+)-R-BAY K 8644 and (-)-R-202-791 inhibited potassium-induced contractions (80 mM K+) in guinea pig ileal longitudinal smooth muscle.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
253
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
905-12
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1694243-3-Pyridinecarboxylic acid..., pubmed-meshheading:1694243-Animals, pubmed-meshheading:1694243-Brain, pubmed-meshheading:1694243-Calcium Channel Agonists, pubmed-meshheading:1694243-Catecholamines, pubmed-meshheading:1694243-Chromatography, High Pressure Liquid, pubmed-meshheading:1694243-Dihydropyridines, pubmed-meshheading:1694243-Guinea Pigs, pubmed-meshheading:1694243-Injections, Intraperitoneal, pubmed-meshheading:1694243-Male, pubmed-meshheading:1694243-Mice, pubmed-meshheading:1694243-Motor Activity, pubmed-meshheading:1694243-Muscle, Smooth, pubmed-meshheading:1694243-Muscle Contraction, pubmed-meshheading:1694243-Nicotinic Acids, pubmed-meshheading:1694243-Nifedipine, pubmed-meshheading:1694243-Oxadiazoles, pubmed-meshheading:1694243-Pyridines, pubmed-meshheading:1694243-Stereoisomerism, pubmed-meshheading:1694243-Structure-Activity Relationship
pubmed:year
1990
pubmed:articleTitle
Comparative behavioral, neurochemical and pharmacological activities of dihydropyridine calcium channel activating drugs.
pubmed:affiliation
Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Canada.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't