Linked Life Data

1694223

Source:http://linkedlifedata.com/resource/pubmed/id/1694223

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-8-1
pubmed:abstractText
We have found that the small population of cells in human marrow that are characterized by their expression of CD34 can be readily subdivided into two apparently nonoverlapping subpopulations of approximate equal size, one expressing CD45RO and one CD45R. Functional studies of these subpopulations revealed that all of the primitive erythroid colony-forming cells (BFU-E) are CD34+ CD45RO+. Similarly, more primitive cells that give rise to both erythroid and granulopoietic colony-forming cells after being maintained for 5 wk on confluent irradiated long-term marrow culture feeder layers, also show this phenotype. In contrast, most granulopoietic colony-forming cells are CD34+ CD45RO- cells. The differential expression of CD45 isoforms on distinct functional subpopulations of hemopoietic cells is consistent with the concept that these molecules play an important role in the differentiation or activation of primitive, normally quiescent, hemopoietic cells. The presence of CD45RO and the lack of CD45R on human cells capable of initiating hemopoiesis in the long-term marrow culture system correspond to the reported lack of CD45R on transplantable hemopoietic stem cells in rodents and may be a useful addition to strategies for human stem cell purification, or for purging CD45R+ leukemic cells.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1694223-2333304, http://linkedlifedata.com/resource/pubmed/commentcorrection/1694223-2417617, http://linkedlifedata.com/resource/pubmed/commentcorrection/1694223-2530588, http://linkedlifedata.com/resource/pubmed/commentcorrection/1694223-2531196, http://linkedlifedata.com/resource/pubmed/commentcorrection/1694223-2790186, http://linkedlifedata.com/resource/pubmed/commentcorrection/1694223-2845400, http://linkedlifedata.com/resource/pubmed/commentcorrection/1694223-2956090, http://linkedlifedata.com/resource/pubmed/commentcorrection/1694223-2964486, http://linkedlifedata.com/resource/pubmed/commentcorrection/1694223-2973067, http://linkedlifedata.com/resource/pubmed/commentcorrection/1694223-2978372, http://linkedlifedata.com/resource/pubmed/commentcorrection/1694223-3297565, http://linkedlifedata.com/resource/pubmed/commentcorrection/1694223-3464448, http://linkedlifedata.com/resource/pubmed/commentcorrection/1694223-3501121, http://linkedlifedata.com/resource/pubmed/commentcorrection/1694223-3758237, http://linkedlifedata.com/resource/pubmed/commentcorrection/1694223-7421991
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
172
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
363-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Selective expression of CD45 isoforms on functional subpopulations of CD34+ hemopoietic cells from human bone marrow.
pubmed:affiliation
Terry Fox Laboratory, Cancer Agency of British Columbia, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't