Source:http://linkedlifedata.com/resource/pubmed/id/16942003
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2006-8-31
|
| pubmed:abstractText |
Lupus anticoagulants (LA) prolong in vitro phospholipid-dependent coagulation tests, but are associated with thromboembolic disease (TE). However, a subgroup of individuals with LA has no TE, and it is therefore desirable to distinguish those at risk for TE from those without. Whether platelets have a primary role in the development of TE is not clear yet. We determined platelet autoantibodies to identify a specific platelet target which is associated with platelet activation in 97 patients with a long history of detectable LA, 65 patients with TE (LA/TE+), and 32 individuals without TE (LA/TE-). Thrombocytopenia was more common in the LA/TE- than in the LA/TE+ group (P < 0.05). Both groups had platelet antibodies, but the frequency of antibodies was lower in LA/TE+ than LA/TE- patients (P < 0.01), who had higher antibody titres against glycoprotein IIb/IIIa and glycoprotein Ib/IX (P < 0.05). Also, their platelets were more activated, as determined by PAC-1 binding (P < 0.01). These differences were also noted if patients with arterial thrombosis were evaluated separately. These findings in LA/TE- individuals were similar to those in patients with chronic autoimmune thrombocytopenia. However, there was no autoantibody target identifiable to distinguish between LA/TE- from LA-TE+ individuals. We therefore conclude that the presence of platelet antibodies, even if associated with platelet activation, is not sufficient to dispose LA patients to thromboembolic disease.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Lupus Coagulation Inhibitor,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/beta 2-Glycoprotein I
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0961-2033
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
507-14
|
| pubmed:meshHeading |
pubmed-meshheading:16942003-Adolescent,
pubmed-meshheading:16942003-Adult,
pubmed-meshheading:16942003-Aged,
pubmed-meshheading:16942003-Antiphospholipid Syndrome,
pubmed-meshheading:16942003-Autoantibodies,
pubmed-meshheading:16942003-Blood Coagulation Tests,
pubmed-meshheading:16942003-Blood Platelets,
pubmed-meshheading:16942003-Child,
pubmed-meshheading:16942003-Female,
pubmed-meshheading:16942003-Humans,
pubmed-meshheading:16942003-Lupus Coagulation Inhibitor,
pubmed-meshheading:16942003-Middle Aged,
pubmed-meshheading:16942003-Platelet Activation,
pubmed-meshheading:16942003-Platelet Membrane Glycoproteins,
pubmed-meshheading:16942003-Random Allocation,
pubmed-meshheading:16942003-Thrombocytopenia,
pubmed-meshheading:16942003-Thromboembolism,
pubmed-meshheading:16942003-beta 2-Glycoprotein I
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Specificities of platelet autoantibodies and platelet activation in lupus anticoagulant patients: a relation to their history of thromboembolic disease.
|
| pubmed:affiliation |
Clinic for Blood Group Serology, Medical University of Vienna, Austria.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|