rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2006-10-12
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pubmed:abstractText |
Checkpoint controls confer order to the cell cycle and help prevent genome instability. Here we discuss the Topoisomerase II (Decatenation) Checkpoint which functions to regulate mitotic progression so that chromosomes can be efficiently condensed in prophase and can be segregated with high fidelity in anaphase.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4,4'-(1,2-dimethyl-1,2-ethanediyl)bi...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Topoisomerases, Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Topoisomerase II Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/pituitary tumor-transforming...
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1551-4005
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pubmed:author |
|
pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1925-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16940751-Chromosomes, Human,
pubmed-meshheading:16940751-DNA Topoisomerases, Type II,
pubmed-meshheading:16940751-Enzyme Inhibitors,
pubmed-meshheading:16940751-Gene Deletion,
pubmed-meshheading:16940751-Humans,
pubmed-meshheading:16940751-Mitosis,
pubmed-meshheading:16940751-Neoplasm Proteins,
pubmed-meshheading:16940751-Piperazines,
pubmed-meshheading:16940751-Topoisomerase II Inhibitors
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pubmed:year |
2006
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pubmed:articleTitle |
Topoisomerase II checkpoints: universal mechanisms that regulate mitosis.
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pubmed:affiliation |
Department of Genetics, Cell Biology & Development, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA. Duncan.J.Clarke-2@umn.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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