Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
2006-8-30
pubmed:abstractText
CD8(+) T lymphocytes control human immunodeficiency virus type 1 (HIV-1) infection by a cytotoxic major histocompatibility complex-restricted pathway as well as by secretion of noncytotoxic soluble inhibitory factors. Several components of CD8(+) cell supernatants have been identified that contribute to the latter activity. In this study we report that prothymosin alpha (ProTalpha), a protein found in the cell culture medium of the herpesvirus saimiri-transformed CD8(+) T-cell line, K#1 50K, has potent HIV-1-inhibitory activity. Depletion of native ProTalpha from an HIV-1-inhibitory fraction of CD8(+) cell supernatants removes the inhibitory activity, supporting its role in inhibition via soluble mediators. ProTalpha is an abundant, acidic peptide that has been reported to be localized in the nucleus and associated with cell proliferation and activation of transcription. In this report we demonstrate that ProTalpha suppresses HIV-1 replication, its activity is target cell specific, and inhibition occurs following viral integration. Native and recombinant ProTalpha protein potently inhibit HIV-1 long terminal repeat (LTR)-driven gene expression in macrophages. Furthermore studies using different promoters in lentiviral vectors (cytomegalovirus and phosphoglycerate kinase) revealed that suppression of viral replication by ProTalpha is not HIV LTR specific.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-10612655, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-10649997, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-10890361, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-10908681, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-11036085, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-11043852, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-11087681, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-11192295, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-11310559, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-11394884, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-11429113, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-11483776, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-11752148, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-11894999, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-11897665, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-11967287, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-12167337, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-12192009, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-12554742, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-12634383, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-12852257, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-14644135, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-14982877, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-15100693, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-15242774, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-15861128, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-16096260, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-2375791, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-2497065, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-2787781, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-2924919, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-3017871, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-3018210, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-3113463, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-3474615, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-7507180, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-7534418, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-7636977, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-8525373, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-8986813, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-9089954, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-9176481, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-9238043, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-9381181, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-9628907, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-9639554, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-9733796, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-9811832, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-9821272, http://linkedlifedata.com/resource/pubmed/commentcorrection/16940531-9933589
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9200-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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