| pubmed-article:16940525 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16940525 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:16940525 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:16940525 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:16940525 | lifeskim:mentions | umls-concept:C0079399 | lld:lifeskim |
| pubmed-article:16940525 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:16940525 | lifeskim:mentions | umls-concept:C0524910 | lld:lifeskim |
| pubmed-article:16940525 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:16940525 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:16940525 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:16940525 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:16940525 | pubmed:dateCreated | 2006-8-30 | lld:pubmed |
| pubmed-article:16940525 | pubmed:abstractText | Elevated levels of interleukin 10 (IL-10) were previously described for chronically hepatitis C virus (HCV)-infected patients. We determined by a sequence-specific oligonucleotide probing technique the IL-10 promoter genotypes in 286 Argentinean HCV patients grouped according to disease outcome. The GG genotype (position -1082) is known to be associated with high IL-10 production, GA is considered an intermediate producer, and AA is associated with low IL-10 production. We found an increase in frequency of the GG genotype in female patients who do not eliminate the virus (RNA(+)). In these patients, the GG frequency was 0.19, versus 0.10 in controls (P = 0.03). This association became more significant in those RNA(+) female patients with elevated hepatic transaminases (GG frequency of 0.25; P = 0.0013). Additionally, this genotype frequency was higher in noncirrhotic female patients than in controls (GG frequency for noncirrhotic female patients was 0.31; P = 0.009). In RNA(-) patients, the GA frequency was elevated compared with that in controls (GA frequency of 0.76 in RNA(-) patients versus 0.48 in controls; P = 0.01), that in all HCV patients (GA frequency of 0.43; P = 0.001), and that in RNA(+) patients (GA frequency of 0.40; P = 0.0005). We conclude that a gender effect is observed with women carrying the GG high IL-10 producer genotype. The higher levels of IL-10 present in those individuals are associated with a higher risk of an inefficient clearance of the HCV and the development of a chronic HCV infection together with a lower risk of progression to cirrhosis in female patients. | lld:pubmed |
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| pubmed-article:16940525 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16940525 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16940525 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16940525 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:16940525 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:16940525 | pubmed:author | pubmed-author:FainboimLeona... | lld:pubmed |
| pubmed-article:16940525 | pubmed:author | pubmed-author:FainboimHugoH | lld:pubmed |
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| pubmed-article:16940525 | pubmed:author | pubmed-author:MuñozAlberto... | lld:pubmed |
| pubmed-article:16940525 | pubmed:author | pubmed-author:GaldameOmarO | lld:pubmed |
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| pubmed-article:16940525 | pubmed:author | pubmed-author:FloresAna... | lld:pubmed |
| pubmed-article:16940525 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16940525 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:16940525 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16940525 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16940525 | pubmed:pagination | 9144-50 | lld:pubmed |
| pubmed-article:16940525 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16940525 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16940525 | pubmed:articleTitle | Gender susceptibility to chronic hepatitis C virus infection associated with interleukin 10 promoter polymorphism. | lld:pubmed |
| pubmed-article:16940525 | pubmed:affiliation | División Inmunogenética, Hospital de Clínicas José de San Martín, Facultad de Medicina, Universidad de Buenos Aires, Av. Córdoba 2351, Buenos Aires 1120, Argentina. | lld:pubmed |
| pubmed-article:16940525 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16940525 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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