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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2006-8-30
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pubmed:abstractText |
Elevated levels of interleukin 10 (IL-10) were previously described for chronically hepatitis C virus (HCV)-infected patients. We determined by a sequence-specific oligonucleotide probing technique the IL-10 promoter genotypes in 286 Argentinean HCV patients grouped according to disease outcome. The GG genotype (position -1082) is known to be associated with high IL-10 production, GA is considered an intermediate producer, and AA is associated with low IL-10 production. We found an increase in frequency of the GG genotype in female patients who do not eliminate the virus (RNA(+)). In these patients, the GG frequency was 0.19, versus 0.10 in controls (P = 0.03). This association became more significant in those RNA(+) female patients with elevated hepatic transaminases (GG frequency of 0.25; P = 0.0013). Additionally, this genotype frequency was higher in noncirrhotic female patients than in controls (GG frequency for noncirrhotic female patients was 0.31; P = 0.009). In RNA(-) patients, the GA frequency was elevated compared with that in controls (GA frequency of 0.76 in RNA(-) patients versus 0.48 in controls; P = 0.01), that in all HCV patients (GA frequency of 0.43; P = 0.001), and that in RNA(+) patients (GA frequency of 0.40; P = 0.0005). We conclude that a gender effect is observed with women carrying the GG high IL-10 producer genotype. The higher levels of IL-10 present in those individuals are associated with a higher risk of an inefficient clearance of the HCV and the development of a chronic HCV infection together with a lower risk of progression to cirrhosis in female patients.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-10421663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-10604568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-10728798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-10733535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-10734016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-11830340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-12121678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-12190181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-12424622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-12671741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-12799024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-12826369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-12927938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-12942209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-14512873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-14697935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-14698136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-15297676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-15345120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-15694997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-15738952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-16006191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-7475549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-7989719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-8707283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-9021963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-9218624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16940525-9672280
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9144-50
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16940525-Adult,
pubmed-meshheading:16940525-Aged,
pubmed-meshheading:16940525-Female,
pubmed-meshheading:16940525-Fibrosis,
pubmed-meshheading:16940525-Genetic Predisposition to Disease,
pubmed-meshheading:16940525-Hepatitis C,
pubmed-meshheading:16940525-Humans,
pubmed-meshheading:16940525-Interleukin-10,
pubmed-meshheading:16940525-Liver,
pubmed-meshheading:16940525-Male,
pubmed-meshheading:16940525-Middle Aged,
pubmed-meshheading:16940525-Polymorphism, Genetic,
pubmed-meshheading:16940525-Promoter Regions, Genetic,
pubmed-meshheading:16940525-Sex Factors
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pubmed:year |
2006
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pubmed:articleTitle |
Gender susceptibility to chronic hepatitis C virus infection associated with interleukin 10 promoter polymorphism.
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pubmed:affiliation |
División Inmunogenética, Hospital de Clínicas José de San Martín, Facultad de Medicina, Universidad de Buenos Aires, Av. Córdoba 2351, Buenos Aires 1120, Argentina.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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