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rdf:type |
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lifeskim:mentions |
umls-concept:C0005847,
umls-concept:C0014257,
umls-concept:C0033268,
umls-concept:C0038836,
umls-concept:C0048897,
umls-concept:C0049315,
umls-concept:C0086418,
umls-concept:C0332161,
umls-concept:C0470187,
umls-concept:C0542341,
umls-concept:C0547047,
umls-concept:C0907532,
umls-concept:C1280500,
umls-concept:C1637379,
umls-concept:C1801960,
umls-concept:C1948027
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pubmed:issue |
11
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pubmed:dateCreated |
2006-9-12
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pubmed:abstractText |
The circulating form of folic acid, 5-methyltetrahydrofolate (5-MTHF), may have beneficial effects on endothelial function; however, its mechanisms of action remain uncertain. Decreased nitric oxide (NO) bioavailability and increased vascular superoxide production in vascular disease states are due in part to endothelial NO synthase (eNOS) uncoupling related to deficiency of the eNOS cofactor tetrahydrobiopterin (BH4), but whether this mechanism is important in human atherosclerosis and represents a rational therapeutic target remains unclear. We hypothesized that 5-MTHF would improve endothelial function by decreasing superoxide and peroxynitrite production and by improving eNOS coupling, mediated by BH4 availability.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/5,6,7,8-tetrahydrobiopterin,
http://linkedlifedata.com/resource/pubmed/chemical/5-methyltetrahydrofolate,
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Biopterin,
http://linkedlifedata.com/resource/pubmed/chemical/Bradykinin,
http://linkedlifedata.com/resource/pubmed/chemical/Homocysteine,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Peroxynitrous Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxides,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydrofolates
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:AntoniadesCharalambosC,
pubmed-author:CaiShijieS,
pubmed-author:ChannonKeith MKM,
pubmed-author:LeeJustinJ,
pubmed-author:LeesonPaulP,
pubmed-author:NeubauerStefanS,
pubmed-author:PillaiRaviR,
pubmed-author:RatnatungaChandiC,
pubmed-author:RefsumHelgaH,
pubmed-author:ShirodariaCheeragC,
pubmed-author:WarrickNicholasN,
pubmed-author:de BonoJosephJ
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pubmed:issnType |
Electronic
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pubmed:day |
12
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1193-201
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16940192-Acetylcholine,
pubmed-meshheading:16940192-Antioxidants,
pubmed-meshheading:16940192-Atherosclerosis,
pubmed-meshheading:16940192-Biological Availability,
pubmed-meshheading:16940192-Biopterin,
pubmed-meshheading:16940192-Bradykinin,
pubmed-meshheading:16940192-Coronary Artery Bypass,
pubmed-meshheading:16940192-Coronary Artery Disease,
pubmed-meshheading:16940192-Double-Blind Method,
pubmed-meshheading:16940192-Endothelium, Vascular,
pubmed-meshheading:16940192-Homocysteine,
pubmed-meshheading:16940192-Humans,
pubmed-meshheading:16940192-Nitric Oxide,
pubmed-meshheading:16940192-Nitric Oxide Synthase Type III,
pubmed-meshheading:16940192-Peroxynitrous Acid,
pubmed-meshheading:16940192-Protein Binding,
pubmed-meshheading:16940192-Superoxides,
pubmed-meshheading:16940192-Tetrahydrofolates
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pubmed:year |
2006
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pubmed:articleTitle |
5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling.
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pubmed:affiliation |
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
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pubmed:publicationType |
Journal Article,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
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