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rdf:type |
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lifeskim:mentions |
umls-concept:C0024501,
umls-concept:C0032105,
umls-concept:C0065055,
umls-concept:C0201950,
umls-concept:C0205054,
umls-concept:C0205224,
umls-concept:C0428466,
umls-concept:C0542341,
umls-concept:C1412058,
umls-concept:C1515655,
umls-concept:C1517058,
umls-concept:C2699782
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pubmed:issue |
12
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pubmed:dateCreated |
2006-9-19
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pubmed:abstractText |
Extrahepatic tissues have long been considered critical contributors of cholesterol to nascent HDL particles in the reverse cholesterol transport pathway, in which ABCA1 plays the crucial role. Recent studies, however, including both overexpression and deletion of ABCA1 selectively in the liver, have highlighted the primary role of the liver in the maintenance of HDL levels in vivo.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:BissadaNagatN,
pubmed-author:BrunhamLiam RLR,
pubmed-author:CollinsHeidi LHL,
pubmed-author:FiévetCatherineC,
pubmed-author:FruchartJean-CharlesJC,
pubmed-author:HaydenAnnaA,
pubmed-author:HaydenMichael RMR,
pubmed-author:HildebrandReeni BRB,
pubmed-author:KangMartin HMH,
pubmed-author:ParksJohn SJS,
pubmed-author:RothblatGeorge HGH,
pubmed-author:SingarajaRoshni RRR,
pubmed-author:StaelsBartB,
pubmed-author:Van BerkelTheo J CTJ,
pubmed-author:Van EckMirandaM,
pubmed-author:ZimettiFrancescaF
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pubmed:issnType |
Electronic
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pubmed:day |
19
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1301-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16940190-ATP-Binding Cassette Transporters,
pubmed-meshheading:16940190-Adenoviridae,
pubmed-meshheading:16940190-Animals,
pubmed-meshheading:16940190-Apolipoprotein A-I,
pubmed-meshheading:16940190-Cholesterol, HDL,
pubmed-meshheading:16940190-Female,
pubmed-meshheading:16940190-Gene Expression Regulation,
pubmed-meshheading:16940190-Humans,
pubmed-meshheading:16940190-Liver,
pubmed-meshheading:16940190-Male,
pubmed-meshheading:16940190-Mice,
pubmed-meshheading:16940190-Mice, Inbred C57BL,
pubmed-meshheading:16940190-Mice, Knockout
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pubmed:year |
2006
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pubmed:articleTitle |
Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo.
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pubmed:affiliation |
Center for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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