|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2006-8-30
|
|
pubmed:abstractText |
In this large population-based cohort study, variants in ESR2 were associated with increased risk of vertebral and incident fragility fracture in postmenopausal women. Interaction of ESR2 with ESR1 and IGF1 was determined and revealed a deleterious genetic combination that enhances the risk of osteoporotic fracture.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0884-0431
|
|
pubmed:author |
pubmed-author:ArpPascalP,
pubmed-author:BeckThomas JTJ,
pubmed-author:HofmanAlbertA,
pubmed-author:Houwing-DuistermaatJeanine JJJ,
pubmed-author:KantJojannekeJ,
pubmed-author:PolsHuibert A PHA,
pubmed-author:RivadeneiraFernandoF,
pubmed-author:SchuitStephanie C ESC,
pubmed-author:StolkLisetteL,
pubmed-author:UitterlindenAndré GAG,
pubmed-author:ZillikensM CarolaMC,
pubmed-author:van DuijnCornelia MCM,
pubmed-author:van LeeuwenJohannes P T MJP,
pubmed-author:van MeursJoyce B JJB
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
21
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1443-56
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16939403-Aged,
pubmed-meshheading:16939403-Aged, 80 and over,
pubmed-meshheading:16939403-Cohort Studies,
pubmed-meshheading:16939403-Estrogen Receptor alpha,
pubmed-meshheading:16939403-Estrogen Receptor beta,
pubmed-meshheading:16939403-Female,
pubmed-meshheading:16939403-Fractures, Bone,
pubmed-meshheading:16939403-Genetic Predisposition to Disease,
pubmed-meshheading:16939403-Haplotypes,
pubmed-meshheading:16939403-Hip,
pubmed-meshheading:16939403-Humans,
pubmed-meshheading:16939403-Insulin-Like Growth Factor I,
pubmed-meshheading:16939403-Linkage Disequilibrium,
pubmed-meshheading:16939403-Middle Aged,
pubmed-meshheading:16939403-Osteoporosis,
pubmed-meshheading:16939403-Osteoporosis, Postmenopausal,
pubmed-meshheading:16939403-Polymorphism, Genetic,
pubmed-meshheading:16939403-Postmenopause,
pubmed-meshheading:16939403-Risk Factors,
pubmed-meshheading:16939403-Spine
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Estrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor alpha (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal women.
|
|
pubmed:affiliation |
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. f.rivadeneira@erasmusmc.nl
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
