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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2006-10-23
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pubmed:abstractText |
We investigated the role of the platelet activation factor (PAF) receptor (PAFR) in the outcome of infection with Leishmania amazonensis. PAFR deficient (PAFR(-/-)) mice were infected with L. amazonensis and the course of infection was followed. We found that PAFR(-/-) mice in the C57BL/6 background were more susceptible to infection with L. amazonensis than the wild-type controls, as seen both by lesion size and parasite number at the site of infection. Interferon (IFN)-gamma production was delayed in PAFR(-/-) mice, and lower levels of Ccl5 were found in lesions. Expression of nitric oxide synthase-2 mRNA was found impaired in PAFR(-/-) associated with higher levels of arginase-1 mRNA. Moreover, higher levels of antibodies were produced in response to L. amazonensis by PAFR(-/-) mice. We conclude that signaling through the PAFR is essential for the ability of the murine host to control L. amazonensis infection by driving an adequate immune response.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/Arginase,
http://linkedlifedata.com/resource/pubmed/chemical/Ccl1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ccl5 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL1,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL5,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/platelet activating factor receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1286-4579
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2569-77
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16938478-Animals,
pubmed-meshheading:16938478-Antibodies, Protozoan,
pubmed-meshheading:16938478-Arginase,
pubmed-meshheading:16938478-Chemokine CCL1,
pubmed-meshheading:16938478-Chemokine CCL5,
pubmed-meshheading:16938478-Chemokines, CC,
pubmed-meshheading:16938478-Disease Models, Animal,
pubmed-meshheading:16938478-Disease Susceptibility,
pubmed-meshheading:16938478-Gene Expression,
pubmed-meshheading:16938478-Histocytochemistry,
pubmed-meshheading:16938478-Immunoglobulin G,
pubmed-meshheading:16938478-Interferon-gamma,
pubmed-meshheading:16938478-Interleukin-10,
pubmed-meshheading:16938478-Leishmania mexicana,
pubmed-meshheading:16938478-Leishmaniasis, Cutaneous,
pubmed-meshheading:16938478-Mice,
pubmed-meshheading:16938478-Mice, Inbred C57BL,
pubmed-meshheading:16938478-Mice, Knockout,
pubmed-meshheading:16938478-Nitric Oxide Synthase Type II,
pubmed-meshheading:16938478-Platelet Membrane Glycoproteins,
pubmed-meshheading:16938478-RNA, Messenger,
pubmed-meshheading:16938478-Receptors, G-Protein-Coupled,
pubmed-meshheading:16938478-Tumor Necrosis Factor-alpha,
pubmed-meshheading:16938478-Up-Regulation
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pubmed:year |
2006
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pubmed:articleTitle |
Platelet activating factor receptor-deficient mice present delayed interferon-gamma upregulation and high susceptibility to Leishmania amazonensis infection.
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pubmed:affiliation |
Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP 486, Av. Antonio Carlos 6627, Pampulha, CEP 30161-970 Belo Horizonte, MG, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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