|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2006-10-3
|
|
pubmed:abstractText |
The E2F3 transcription factor has an established role in controlling cell cycle progression. In previous studies we have provided evidence that nuclear E2F3 overexpression represents a mechanism that drives the development of human bladder cancer and that determines aggressiveness in human prostate cancer. We have proposed a model in which E2F3 overexpression co-operates with removal of the E2F inhibitor pRB to facilitate cancer development. Since small cell lung cancers (SCLC) have one of the highest reported frequencies of functional abnormalities in the pRB protein (90%) of any human cancer, we wish to assess to what extent E2F3 would be overexpressed in this and other classes of human lung cancer.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0169-5002
|
|
pubmed:author |
pubmed-author:ChengShu-JunSJ,
pubmed-author:ClarkJeremyJ,
pubmed-author:CooperColin SCS,
pubmed-author:DodsonAndrewA,
pubmed-author:EdwardsSandraS,
pubmed-author:FeberAndrewA,
pubmed-author:FletcherAnneA,
pubmed-author:FosterChristopherC,
pubmed-author:GaoYanningY,
pubmed-author:JoshiAnupamA,
pubmed-author:LinDongmeiD,
pubmed-author:NicholsonAndrew GAG,
pubmed-author:NormanAndrewA,
pubmed-author:RoeTobyT,
pubmed-author:ShipleyJanetJ
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
54
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
155-62
|
|
pubmed:meshHeading |
pubmed-meshheading:16938365-Adenocarcinoma,
pubmed-meshheading:16938365-Carcinoid Tumor,
pubmed-meshheading:16938365-Carcinoma, Neuroendocrine,
pubmed-meshheading:16938365-Carcinoma, Small Cell,
pubmed-meshheading:16938365-Carcinoma, Squamous Cell,
pubmed-meshheading:16938365-Cell Nucleus,
pubmed-meshheading:16938365-E2F3 Transcription Factor,
pubmed-meshheading:16938365-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16938365-Genes, Retinoblastoma,
pubmed-meshheading:16938365-Humans,
pubmed-meshheading:16938365-Immunohistochemistry,
pubmed-meshheading:16938365-Lung Neoplasms,
pubmed-meshheading:16938365-Oligonucleotide Array Sequence Analysis
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Nuclear overexpression of the E2F3 transcription factor in human lung cancer.
|
|
pubmed:affiliation |
Section of Molecular Carcinogenesis, Male Urological Cancer Research Centre, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK. colin.cooper@icr.ac.uk
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
