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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2006-10-3
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pubmed:abstractText |
It is assumed that the retinoid X receptor (RXR) acts as a silent partner to the vitamin D receptor (VDR) with its only function to increase affinity of VDR/RXR to its DNA recognition site. In this study, we show that the RXR ligand 9-cis-retinoic acid (9-cis-RA) induces recruitment of coactivators by the DNA-bound heterodimer and potentiates vitamin D-dependent transcriptional responses. The presence of 9-cis-RA increases induction of cyp24 transcripts and differentiation of colon cancer cells by vitamin D, confers significant agonistic activity to a VDR ligand with very low agonistic activity and can even restore transcriptional activity of an AF-2 mutant VDR that causes hereditary rickets. This study shows that, in VDR/RXR heterodimers, allosteric communication triggered by the RXR ligand has a previously unrecognized role in vitamin D signalling, with important physiological and therapeutic implications.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16936639-10224118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16936639-10748178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16936639-11427696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16936639-11470825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16936639-11805839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16936639-12403843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16936639-12893883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16936639-14701725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16936639-15016376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16936639-15055995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16936639-15065852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16936639-15650022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16936639-9192902
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Histone Acetyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Mutant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NCOA1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/NCOA2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/NCOA3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Coactivator 1,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Coactivator 2,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Coactivator 3,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Calcitriol,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoid X Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tretinoin,
http://linkedlifedata.com/resource/pubmed/chemical/alitretinoin
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1469-221X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1030-4
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16936639-Cell Differentiation,
pubmed-meshheading:16936639-Dimerization,
pubmed-meshheading:16936639-Histone Acetyltransferases,
pubmed-meshheading:16936639-Humans,
pubmed-meshheading:16936639-Ligands,
pubmed-meshheading:16936639-Mutant Proteins,
pubmed-meshheading:16936639-Nuclear Receptor Coactivator 1,
pubmed-meshheading:16936639-Nuclear Receptor Coactivator 2,
pubmed-meshheading:16936639-Nuclear Receptor Coactivator 3,
pubmed-meshheading:16936639-Protein Binding,
pubmed-meshheading:16936639-Receptors, Calcitriol,
pubmed-meshheading:16936639-Retinoid X Receptors,
pubmed-meshheading:16936639-Signal Transduction,
pubmed-meshheading:16936639-Trans-Activators,
pubmed-meshheading:16936639-Transcription Factors,
pubmed-meshheading:16936639-Transcriptional Activation,
pubmed-meshheading:16936639-Tretinoin,
pubmed-meshheading:16936639-Tumor Cells, Cultured
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pubmed:year |
2006
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pubmed:articleTitle |
The retinoid X receptor ligand restores defective signalling by the vitamin D receptor.
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pubmed:affiliation |
Instituto de Investigaciones Biomédicas, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Arturo Duperier 4, Madrid 28029, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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