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rdf:type |
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lifeskim:mentions |
umls-concept:C0006675,
umls-concept:C0017262,
umls-concept:C0019868,
umls-concept:C0020456,
umls-concept:C0027882,
umls-concept:C0035331,
umls-concept:C0185117,
umls-concept:C0392747,
umls-concept:C1711351,
umls-concept:C2911684,
umls-concept:C2936399
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pubmed:issue |
9
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pubmed:dateCreated |
2006-8-28
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pubmed:abstractText |
Altered glutamatergic neurotransmission and calcium homeostasis may contribute to retinal neural cell dysfunction and apoptosis in diabetic retinopathy (DR). The purpose of this study was to determine the effect of high glucose on the protein content of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) and kainate glutamate receptor subunits, particularly the GluR2 subunit, because it controls Ca2+ permeability of AMPA receptor-associated channels. The effect of high glucose on the concentration of cytosolic free calcium ([Ca2+]i) was also investigated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aniline Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Fluo 4,
http://linkedlifedata.com/resource/pubmed/chemical/GRIK5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Subunits,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, AMPA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthenes
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4130-7
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pubmed:dateRevised |
2007-6-20
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pubmed:meshHeading |
pubmed-meshheading:16936133-Aniline Compounds,
pubmed-meshheading:16936133-Animals,
pubmed-meshheading:16936133-Animals, Newborn,
pubmed-meshheading:16936133-Blotting, Western,
pubmed-meshheading:16936133-Calcium,
pubmed-meshheading:16936133-Cells, Cultured,
pubmed-meshheading:16936133-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:16936133-Glucose,
pubmed-meshheading:16936133-Homeostasis,
pubmed-meshheading:16936133-Microscopy, Confocal,
pubmed-meshheading:16936133-Neurons,
pubmed-meshheading:16936133-Protein Subunits,
pubmed-meshheading:16936133-Rats,
pubmed-meshheading:16936133-Rats, Sprague-Dawley,
pubmed-meshheading:16936133-Receptors, AMPA,
pubmed-meshheading:16936133-Receptors, Kainic Acid,
pubmed-meshheading:16936133-Retina,
pubmed-meshheading:16936133-Xanthenes
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pubmed:year |
2006
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pubmed:articleTitle |
Elevated glucose changes the expression of ionotropic glutamate receptor subunits and impairs calcium homeostasis in retinal neural cells.
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pubmed:affiliation |
Center for Neuroscience and Cell Biology, Department of Zoology, Penn State College of Medicine, Hershey, PA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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